Pathophysiological relationship ofmitochondria to neuronal death during brain ischemia
Pathophysiological relationship ofmitochondria to neuronal death during brain ischemia
批准号:
22790256
负责人:
KANBE Yuki
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Pituitary adenylate cyclase-activating polypeptide (PACAP) increases neurite outgrowth in many kind of neuronal cells, but signaling via its receptor PACAP-specific receptor has not been fully characterized. Because mitochondria also play an important role in neurodevelopment including dendritic branching, axonal guidanceand neurite outgrowth, we examined whether mitochondria contribute to PACAP-mediated neurite outgrowth. Present data suggest that mitochondrial activation plays a key role in PACAP-induced neurite outgrowth via a signaling pathway that includes PAC1R, PKA, andPgc1α.
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Intra-cellular translocation of Pgc1α is involved in PACAP induced neurite outgrowth in neuronal cells
Pgc1α 的细胞内易位参与 PACAP 诱导神经元细胞中的神经突生长
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara and Atsuro Miyata]
通讯作者:
Takashi Kurihara and Atsuro Miyata
生体情報薬理学
生物信息药理学
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1016/j.neuint.2011.03.018
发表时间:
2011-08-01
期刊:
NEUROCHEMISTRY INTERNATIONAL
影响因子:
4.2
作者:
[Kambe, Yuki, Nakamichi, Noritaka, Yoneda, Yukio]
通讯作者:
Yoneda, Yukio
From mitochondria to nucleus, Pgc-1 translocation may be one of the key factors for neurite extension in N2a cells
从线粒体到细胞核,Pgc-1易位可能是N2a细胞神经突延伸的关键因素之一
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yuki Kambe, Atsuro Miyata]
通讯作者:
Atsuro Miyata
DOI:
10.1016/j.bbrc.2012.01.027
发表时间:
2012-02-10
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Takenouchi, Rina, Inoue, Kazuhiko, Miyata, Atsuro]
通讯作者:
Miyata, Atsuro
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