Pathophysiological relationship ofmitochondria to neuronal death during brain ischemia

脑缺血时线粒体与神经元死亡的病理生理关系

• 批准号: 22790256
• 负责人: KANBE Yuki
• 金额: $ 2.58万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790256/
• 关键词: 神経細胞死; 細胞内情報伝達; ミトコンドリア; 脳神経疾患; シグナル伝達; 脳・神経疾患

Pituitary adenylate cyclase-activating polypeptide (PACAP) increases neurite outgrowth in many kind of neuronal cells, but signaling via its receptor PACAP-specific receptor has not been fully characterized. Because mitochondria also play an important role in neurodevelopment including dendritic branching, axonal guidanceand neurite outgrowth, we examined whether mitochondria contribute to PACAP-mediated neurite outgrowth. Present data suggest that mitochondrial activation plays a key role in PACAP-induced neurite outgrowth via a signaling pathway that includes PAC1R, PKA, andPgc1α.

垂体腺苷酸环化酶激活多肽 (PACAP) 可增加多种神经元细胞中的神经突生长，但通过其受体 PACAP 特异性受体进行的信号传导尚未得到充分表征。由于线粒体在神经发育（包括树突分支、轴突引导和神经突生长）中也发挥着重要作用，因此我们研究了线粒体是否有助于 PACAP 介导的神经突生长。目前的数据表明，线粒体激活通过包括 PAC1R、PKA 和 Pgc1α 在内的信号通路在 PACAP 诱导的神经突生长中发挥关键作用。

项目成果

Intra-cellular translocation of Pgc1α is involved in PACAP induced neurite outgrowth in neuronal cells

Pgc1α 的细胞内易位参与 PACAP 诱导神经元细胞中的神经突生长

• 发表时间: 2011
• 作者: Yuki Kambe;Kazuhiko Inoue;Takashi Kurihara and Atsuro Miyata
• 通讯作者: Takashi Kurihara and Atsuro Miyata

A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons

• DOI: 10.1016/j.neuint.2011.03.018
• 发表时间: 2011-08-01
• 期刊: NEUROCHEMISTRY INTERNATIONAL
• 影响因子: 4.2
• 作者: Kambe, Yuki;Nakamichi, Noritaka;Yoneda, Yukio
• 通讯作者: Yoneda, Yukio

生体情報薬理学

生物信息药理学

From mitochondria to nucleus, Pgc-1 translocation may be one of the key factors for neurite extension in N2a cells

从线粒体到细胞核，Pgc-1易位可能是N2a细胞神经突延伸的关键因素之一

• 发表时间: 2010
• 作者: Yuki Kambe;Atsuro Miyata
• 通讯作者: Atsuro Miyata

N-arachidonoyl glycine induces macrophage apoptosis via GPR18

• DOI: 10.1016/j.bbrc.2012.01.027
• 发表时间: 2012-02-10
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takenouchi, Rina;Inoue, Kazuhiko;Miyata, Atsuro
• 通讯作者: Miyata, Atsuro