Neuron-Specific Function of N-TAF1, the disease causative gene of Hereditary Dystonia(DYT3)

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We previously found a neuron-specific isoform of the TAF1, which is the disease causative gene of X-linked recessive dystonia-parkinsonism. To investigate the function of the neuron-specific isoform of the TAF1 gene, we carried out over-expression of TAF1 in neuronal and non-neuronal cultured cell lines. We demonstrated that the localization pattern of TAF1 is different between neuronal and non-neuronal cell. And we performed knockdown of either TAF1 or N-TAF1 using siRNA. The microarray analysis showed some candidate gene which might be regulated by N-TAF1.