Analytical epidemiological study on the risk and the primary prevention of cataract, glaucoma, and age-related macular degeneration

这项为期5年的前瞻性人群研究基于一组日本居民的数据，旨在阐明年龄相关性白内障与体重指数(BMI)的关系。结果表明，在日本男性和女性中，体重指数和白内障发病率之间存在U型关系。BMI最低(19.0)和最高(25.0)BMI类别的白内障的多变量优势比为21.0-22.9。在这项横断面和纵向研究中，我们试图阐明血压(BP)、BMI和吸烟是否与眼压升高有关。研究结果表明，血压和BMI与眼压呈显著正相关，吸烟与高眼压，尤其是“高血压伴高眼压”有关。BP和BMI的纵向变化(平均3.6年随访期)与眼压呈显著正相关。

This 5-year prospective population-based study was conducted, based on the data of a cohort of Japanese residents, in order to clarify the relationship of age-related cataracts to body mass index (BMI). The results demonstrated a U-shaped association between BMI and the incidence of cataract in Japanese men and women. The multivariate odds ratios of cataract for those in the lowest (<19.0) and the highest (>25.0) BMI categories, compared with a BMI category of 21.0-22.9.In this cross-sectional and longitudinal studies, we attempted to clarify whether blood pressure (BP), BMI, and smoking was associated with elevated intraocular pressure (IOP). The results of this study showed suggest that BP and BMI had a significantly positive association with IOP and that smoking was associated with high IOP, especially with "high BP accompanied by high IOP". Longitudinal changes (average follow-up period of 3.6 years) in BP and BMI also had a significant positive association with that of IOP.