Analytical epidemiological study on the risk and the primary prevention of cataract, glaucoma, and age-related macular degeneration

白内障、青光眼及年龄相关性黄斑变性的风险及一级预防分析流行病学研究

• 批准号: 22790570
• 负责人: YOSHIDA Masao
• 金额: $ 1.75万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790570/
• 关键词: 白内障; 緑内障; 眼圧; 予防医学; 疫学; コホート研究; 加齢黄斑変性; 疫学研究

This 5-year prospective population-based study was conducted, based on the data of a cohort of Japanese residents, in order to clarify the relationship of age-related cataracts to body mass index (BMI). The results demonstrated a U-shaped association between BMI and the incidence of cataract in Japanese men and women. The multivariate odds ratios of cataract for those in the lowest (<19.0) and the highest (>25.0) BMI categories, compared with a BMI category of 21.0-22.9.In this cross-sectional and longitudinal studies, we attempted to clarify whether blood pressure (BP), BMI, and smoking was associated with elevated intraocular pressure (IOP). The results of this study showed suggest that BP and BMI had a significantly positive association with IOP and that smoking was associated with high IOP, especially with "high BP accompanied by high IOP". Longitudinal changes (average follow-up period of 3.6 years) in BP and BMI also had a significant positive association with that of IOP.

这项为期5年的前瞻性人群研究是根据一组日本居民的数据进行的，目的是阐明年龄相关性白内障与体重指数（BMI）的关系。结果表明，日本男性和女性的BMI与白内障发病率之间存在U形关联。BMI最低（<19.0）和BMI最高（>25.0）人群白内障的多变量优势比（OR）与BMI为21.0- 22.9人群白内障的多变量优势比（OR）比较。研究结果提示：血压、体重指数与眼压呈显著正相关，吸烟与高眼压有关，尤其是与“高血压伴高眼压”有关。BP和BMI的纵向变化（平均随访时间为3.6年）也与IOP呈显著正相关。

项目成果

Association of blood pressure and body mass index with intraocular pressure in middle-aged and older Japanese residents

日本中老年居民血压、体重指数与眼压的关系

• DOI: 10.3861/jshhe.79.99
• 发表时间: 2013
• 期刊: Japanese Journal of Health and Human Ecology
• 作者: Yoshida M;Ishikawa M;Kokaze A;Harada M & Karita K
• 通讯作者: Harada M & Karita K

肥満度および血圧値の変化が眼圧値の変動に及ぼす影響 ～1年間の縦断研究～

肥胖程度和血压变化对眼压波动的影响～1年纵向研究～

• 发表时间: 2012
• 作者: 吉田正雄;石川 守;小風 暁;原田まつ子;苅田香苗
• 通讯作者: 苅田香苗

Association of blood pressure and body mass index with intraocular pressure in middle-aged and older Japanese Residents : A cross-sectional and longitudinal study.

日本中老年居民血压和体重指数与眼压的关联：一项横断面和纵向研究。

• 发表时间: 2014
• 期刊: Acta Med Okayama
• 影响因子: 0.5
• 作者: Yoshida;M.;et al.
• 通讯作者: et al.

多目的コホート研究(JPHC Study)における白内障のリスク要因と一次予防対策解明のための分析疫学的研究 ～BMI と白内障発生率との関係～

通过多目的队列研究（JPHC研究）阐明白内障危险因素和一级预防措施的分析流行病学研究〜BMI与白内障发病率之间的关系〜

• 发表时间: 2013
• 作者: 吉田正雄;井上真奈美;岩崎 基;苅田香苗;岳 真一郎;津金昌一郎
• 通讯作者: 津金昌一郎

眼圧値の変動に関連する因子と緑内障一次予防対策解明のための分析疫学的研究～1年間の縦断研究～

阐明眼压波动相关因素和青光眼一级预防措施的分析流行病学研究〜1年纵向研究〜

• 发表时间: 2012
• 作者: Ohtomo T;Miyazawa K;Naito M;Moriya S;Kuroda M;Itoh M;Tomoda A;吉田正雄
• 通讯作者: 吉田正雄