Association between genetic and clinical characteristics and tailor made therapy in idiopathic ventricular fibrillation

特发性心室颤动的遗传和临床特征之间的关联以及定制治疗

• 批准号: 22790696
• 负责人: WATANABE Hiroshi
• 金额: $ 2.25万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790696/
• 关键词: 不整脈; 心電図; 遺伝子; イオンチャネル; リスクファクター

There has been increasing interest in idiopathic ventricular fibrillation, but the clinical characteristics, underlying mechanisms, and genetic background are unclear. Furthermore, the data for risk stratification to prevent sudden death is not enough. We identified clinical characteristics, novel genetic background, and the underlying mechanisms in idiopathic ventricular fibrillation. We also found risk factors for arrhythmia recurrences that are useful for tailor made therapy.

特发性室颤的研究日益受到重视，但其临床特征、发病机制和遗传背景尚不清楚。此外，用于预防猝死的危险分层的数据也不够。我们确定了特发性室颤的临床特征、新的遗传背景和潜在机制。我们还发现了心律失常复发的危险因素，这些因素对量身定制的治疗是有用的。

项目成果

Suppression of storms of ventricular tachycardia by epicardial ablation of isolated delayed potential in noncompaction cardiomyopathy

心外膜消融孤立性迟发性心肌病抑制室性心动过速风暴

• 发表时间: 2011
• 期刊: Pacing Clin Electrophysiol
• 作者: Chinushi M;Iijima K;Furushima H;Izumi D;Sato A;Yagihara N;Hasegawa K;Watanabe H;Soejima K;Aizawa Y
• 通讯作者: Aizawa Y

Exercise‐Related QT Interval Shortening with a Peaked T Wave in a Healthy Boy with a Family History of Sudden Cardiac Death

有心脏性猝死家族史的健康男孩与运动相关的 QT 间期缩短并伴有 T 波峰值

• 发表时间: 2012
• 期刊: Pacing and clinical electrophysiology : PACE
• 作者: M. Chinushi;A. Sato;K. Iijima;Katuya Suzuki;Furushima Hiroshi;D. Izumi;Hiroshi Watanabe;Hasegawa Kanae;Y. Aizawa
• 通讯作者: Y. Aizawa

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.

• DOI: 10.1161/circresaha.110.235630
• 发表时间: 2011-06-24
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Atack TC;Stroud DM;Watanabe H;Yang T;Hall L;Hipkens SB;Lowe JS;Leake B;Magnuson MA;Yang P;Roden DM
• 通讯作者: Roden DM

Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization

• DOI: 10.1161/circep.111.963983
• 发表时间: 2011-12-01
• 期刊: CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
• 影响因子: 8.4
• 作者: Watanabe, Hiroshi;Nogami, Akihiko;Makita, Naomasa
• 通讯作者: Makita, Naomasa

Is the coexistence of sustained ST-segment elevation and abnormal Q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases?

持续ST段抬高和异常Q波共存是否是植入式心脏复律除颤器的结构性心脏病患者发生电风暴的危险因素？

• 发表时间: 2012
• 期刊: Europace
• 影响因子: 6.1
• 作者: Furushima H;Chinushi M;Iijima K;Hasegawa K;Sato A;Izumi D;Watanabe H;Aizawa Y.
• 通讯作者: Aizawa Y.