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Analysis of intestinal cholesterol absorption for the personalized medicine against hypercholesterolemia

Analysis of intestinal cholesterol absorption for the personalized medicine against hypercholesterolemia
高胆固醇血症个体化用药的肠道胆固醇吸收分析
批准号:
21790152
负责人:
WATANABE Hiroshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
We show that, when parental Chinese hamster ovary (CHO) cells are briefly exposed to ^3H-cholesteryl linoleate (CL) labeled-LDL, newly liberated ^3H-LDL-CHOL appears in membranes rich in trans-Golgi network (TGN) long before it becomes available for re-esterification at the endoplasmic reticulum (ER) or for efflux at the plasma membrane. In mutant cells lacking NPC1, the appearance of newly liberated ^3H-LDL-CHOL in the TGN-rich fractions is much reduced. We demonstrate that knockdown by RNAi of 3 TGN-specific SNAREs (VAMP4, syntaxin 6, and syntaxin 16) reduces >/=50% of the LDL-CHOL transport in intact cells and in vitro.
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会议论文
一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する
负载一氧化碳的红细胞在大出血期间保护肝细胞色素 P450
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [大柿滋, 田口和明, 渡邉博志, 小田切優樹, 丸山徹]
通讯作者: 丸山徹
THE DETECTION OF ENDOGENOUS S-GUANYLATED HUMAN SERUM ALBUMIN
内源性S-鸟苷酸人血清白蛋白的检测
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Hozawa A, Tsuji I, et al, Hoshino H]
通讯作者: Hoshino H
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Cologne, John, 宮里麻友美]
通讯作者: 宮里麻友美
Pharmacokinetic profiles of hemoglobin-vesicles as an artificial oxygen carrier
血红蛋白囊泡作为人工氧载体的药代动力学特征
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Ma N, Sasaki T, Sakata-Haga H, Ohta K, Gao M, Kawanishi S, Fukui Y, Taguchi K]
通讯作者: Taguchi K
65
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