Analysis of intestinal cholesterol absorption for the personalized medicine against hypercholesterolemia
Analysis of intestinal cholesterol absorption for the personalized medicine against hypercholesterolemia
批准号:
21790152
负责人:
WATANABE Hiroshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
We show that, when parental Chinese hamster ovary (CHO) cells are briefly exposed to ^3H-cholesteryl linoleate (CL) labeled-LDL, newly liberated ^3H-LDL-CHOL appears in membranes rich in trans-Golgi network (TGN) long before it becomes available for re-esterification at the endoplasmic reticulum (ER) or for efflux at the plasma membrane. In mutant cells lacking NPC1, the appearance of newly liberated ^3H-LDL-CHOL in the TGN-rich fractions is much reduced. We demonstrate that knockdown by RNAi of 3 TGN-specific SNAREs (VAMP4, syntaxin 6, and syntaxin 16) reduces >/=50% of the LDL-CHOL transport in intact cells and in vitro.
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一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する
负载一氧化碳的红细胞在大出血期间保护肝细胞色素 P450
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大柿滋, 田口和明, 渡邉博志, 小田切優樹, 丸山徹]
通讯作者:
丸山徹
THE DETECTION OF ENDOGENOUS S-GUANYLATED HUMAN SERUM ALBUMIN
内源性S-鸟苷酸人血清白蛋白的检测
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Hozawa A, Tsuji I, et al, Hoshino H]
通讯作者:
Hoshino H
四塩化炭素誘発肝障害モデルラットにおけるヘモグロビン小胞体の体内動態の評価
四氯化碳肝损伤模型大鼠血红蛋白内质网药动学评价
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Cologne, John, 宮里麻友美]
通讯作者:
宮里麻友美
Pharmacokinetic profiles of hemoglobin-vesicles as an artificial oxygen carrier
血红蛋白囊泡作为人工氧载体的药代动力学特征
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ma N, Sasaki T, Sakata-Haga H, Ohta K, Gao M, Kawanishi S, Fukui Y, Taguchi K]
通讯作者:
Taguchi K
ヘモグロビン小胞体の体内動態の検討
血红蛋白内质网药代动力学检查
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Hiraku Y, Kawanishi S, 異島優, Hayashi T, Tada-Oikawa S, 田口和明]
通讯作者:
田口和明
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Followership as a Reflection of Leadership - Middle Manager's Experience and Succession at Work -
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批准号:18K12856
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项目类别:Grant-in-Aid for Early-Career Scientists
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"1968" from the Viewpoint of Visual/Auditory Culture: Reconsidering post-war History in Japan
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Feedback between Chain Dynamics and Phase Separation in Polymer Blends
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批准号:24245045
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资助金额:$29.45万
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Empirical Study of Barriers against "Bad News" Communication within the Organization
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Construction of a comprehensive support system that utilizes the regional network for elementary school "science" support
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Association between genetic and clinical characteristics and tailor made therapy in idiopathic ventricular fibrillation
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Effects of thermodynamic and spatial constraints on dynamics of block copolymers
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Study for biofilm formed by Streptococcus pneumoniae and the treatment strategy
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Development and evaluation for design method of middle span timber bridges considering their costs and maintenance
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Research on the deterioration mechanism and maintenance of concrete structures deteriorated due to the macro-cell corrosion in concrete
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Theoretical Study of Non-Hermitian Dynamics on the Basis of the Classical Mechanics
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Development of the biodegradable graft for cardiovascular surgery with function of local release of growth factors and cytokines
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Clinical study concerning the relationship between community-acquiredpneumonia and influenza in Thailand
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Calcium entry channel related gene expression profiles of endothelial cells by micro-bead array analysis and target gene identification for drug discovery
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Study for biofilm formed by Haemophilus influenzae on human bronchial epithelial cells
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海外基金