Regeneration of neo-kidney using chicken embryos

人间充质干细胞（hMSCs）转染肾发育必需基因Pax2或Lim1后，可移植到鸡胚中分化为输尿管芽。肾脏器官发生的基因表达模式与鸡胚胎和人类相同。此外，鸡胚胎不是胎生的，而且相对较大，因此更容易被操纵。提示鸡胚是制备人新肾的合适器官工厂。

Human mesenchymal stem cells (hMSCs) transfected with Pax2 or Lim1, whicn is the essential gene for kidney development, can differentiate into the ureteric bud by their transplantation into chicken embryos. The gene expression patterns of kidney organogenesis are identical to chicken embryos and humans. Moreover, chicken embryos are easier to be manipulated because they are not viviparous and relatively large. It suggests that chicken embryos are appropriate organ factory for generating human neo-kidney.