Role of sympathetic nervous system in diurnal fluctuation of intraocular pressure

眼内压（IOP）是青光眼最重要的已确定危险因素，昼夜IOP波动是另一个可影响青光眼发展的危险因素。我们分析了未经治疗的正常眼压性青光眼患者肾上腺素能受体（ADR）基因多态性与昼夜眼压的关系。α2B-ADR的Del 301-303、α2C-ADR的Del 322-325和β1-ADR的S49 G（A/G）重复测量方差分析结果显示，主等位基因纯合子和次等位基因携带者的昼夜眼压曲线平行，但昼夜眼压水平差异显著。

Intraocular pressure (IOP) is the most important identified risk factor of glaucoma and diurnal IOP fluctuations are another risk factor that can influence development of glaucoma. We analyzed the relationship between genetic polymorphisms of the adrenergic receptor (ADR) and diurnal IOP in untreated normal tension glaucomapatients. For Del 301-303 in α2B-ADR, Del 322-325 in α2C-ADR, and S49G (A/G) in β1-ADR, results of repeated measures analysis of variance showed that the major allele homozygote and minor allele carrier had parallel diurnal IOP curves but significantly different diurnal IOP levels.