Effect to immunoresponse of antibacterial peptides

抗菌肽对免疫反应的影响

• 批准号: 22592095
• 负责人: KANBARA Kenji
• 金额: $ 2.83万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592095/
• 关键词: LL-37; LL37; DNA; TLR9; 歯周病態形成; サイトカイン; TLR-9

In this study, it was demonstrated that LL-37 interacted with bacterial DNA/RNA and these complexes were tolerated to several nuclease. Furthermore, LL-37 interacted to apolipoprotein-A1(Apo-A1) which is a component of high density lipoprotein. It was considered that these complexes stimulate immune system effectively for a long time and LL-37-Apo-A1 complexes may be associated between metabolic syndrome. Those complexes tend to increase expression of CXCL10 in gingival epithelia cells, Ca9-22 cells. However, we have been not confirming increase of CXCL10 protein secretion level yet.

在这项研究中，它被证明LL-37与细菌DNA/RNA相互作用，这些复合物是耐受几种核酸酶。此外，LL-37与载脂蛋白-A1（Apo-A1）相互作用，载脂蛋白-A1是高密度脂蛋白的组分。认为这些复合物能长时间有效地刺激免疫系统，LL-37-Apo-A1复合物可能与代谢综合征有关。这些复合物倾向于增加牙龈上皮细胞，Ca 9 -22细胞中CXCL 10的表达。然而，我们尚未证实CXCL 10蛋白分泌水平增加。

项目成果

Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms.

• DOI: 10.1111/j.2041-1014.2012.00637.x
• 发表时间: 2012-04
• 期刊: Molecular oral microbiology
• 影响因子: 3.7
• 作者: Y. Mazda;M. Kawada-Matsuo;K. Kanbara;Y. Oogai;Y. Shibata;Y. Yamashita;S. Miyawaki;H. Komatsuzawa

Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells.

• DOI: 10.1111/j.1600-0765.2012.01524.x
• 发表时间: 2013-04
• 期刊: Journal of periodontal research
• 影响因子: 3.5
• 作者: M. Kittaka;H. Shiba;M. Kajiya;K. Ouhara;K. Takeda;K. Kanbara;T. Fujita;H. Kawaguchi;H. Komatsuzawa;H. Kurihara

汗中の抗菌性ペプチドの定量

汗液中抗菌肽的定量

• 发表时间: 2012
• 作者: Shiraishi T;Chikui T;Yoshiura K and Yuasa K;神原賢治
• 通讯作者: 神原賢治