Effect to immunoresponse of antibacterial peptides

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In this study, it was demonstrated that LL-37 interacted with bacterial DNA/RNA and these complexes were tolerated to several nuclease. Furthermore, LL-37 interacted to apolipoprotein-A1(Apo-A1) which is a component of high density lipoprotein. It was considered that these complexes stimulate immune system effectively for a long time and LL-37-Apo-A1 complexes may be associated between metabolic syndrome. Those complexes tend to increase expression of CXCL10 in gingival epithelia cells, Ca9-22 cells. However, we have been not confirming increase of CXCL10 protein secretion level yet.