Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement

近年来，锌释放生物陶瓷因其具有良好的成骨能力而备受关注。因此，研究了某些类型的含锌磷酸钙（例如，锌掺杂磷酸三钙和锌取代羟基磷灰石），并确定了它们的成骨细胞反应。在这项研究中，我们研究了磷酸锌衍生的磷酸钙锌（ZCP）掺入磷酸钙水泥（CPC）对其固化反应和MC3T3-E1成骨样细胞反应的影响。添加10 wt% ZCP后，细胞增殖能力增强，碱性磷酸酶（ALP）活性增强。综上所述，ZCP添加适当比例的CPC对骨替代生物材料具有潜在的促进作用。

Recently, zinc-releasing bioceramics have been the focus of much attention owing to their bone-forming ability. Thus, some types of zinc-containing calcium phosphate (e.g., zinc-doped tricalcium phosphate and zinc-substituted hydroxyapatite) are examined and their osteoblastic cell responses determined. In this investigation, we studied the effects of zinc calcium phosphate(ZCP) derived from zinc phosphate incorporated into calcium phosphate cement (CPC) in terms of its setting reaction and MC3T3-E1 osteoblast-like cell responses. The proliferation of the cells and alkaline phosphatase (ALP) activity were enhanced when 10 wt% ZCP was added to CPC. Taken together, ZCP added CPC at an appropriate fraction has a potentpromotive effect on bone substitute biomaterials.