Inter-generational effect of a mother and her mother as revealed in their Maternal and Child Health Handbooks

近年来，日本的出生人数有所下降，而出生体重过低的婴儿数量有所增加。研究人员认为，低出生体重是胎儿期和婴儿期营养失调和环境因素的结果，这是健康和疾病发育起源理论（DOHaD）。在这项研究中，我们纳入了2000年以来从新生儿重症监护病房出院的小于胎龄（SGA）婴儿作为研究对象。采用修订后的小学生评定量表（PRS）和儿童抑郁量表（CDI），我们调查了宫内环境是否与随后的生长、行为发展和心理健康有关；并且，如果存在这样的关系，阐明宫内环境如何影响这些变量。

In recent years, there has been a decline in the number of births in Japan and an increase in the number of infants with low birth weight. Researchers suggest that low birth weight is the result of nutritional disorders and environmental factors during the fetal period and infancy, which is the theory of the developmental origins of health and disease (DOHaD). In this study, we included small for gestational age (SGA) infants who were discharged from neonatal intensive care units and were given follow-up since 2000 as subjects. Using the Pupil Rating Scale Revised (PRS) and the Children’s Depression Inventory (CDI), we investigated whether intrauterine environment relates to subsequent growth, behavioral development, and mental health; and, if there are such relations, to elucidate how intrauterine environment influences these variables.