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Study of a role of sympathetic nerves on a novel K+ channel in neuropathic pain.

Study of a role of sympathetic nerves on a novel K+ channel in neuropathic pain.
研究交感神经对新型 K 通道在神经性疼痛中的作用。
批准号:
22600013
负责人:
YAMAMOTO Satoshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
翻译
为探讨神经病理性疼痛的发生机制,研究了一种新的热激活K+通道在背根神经节神经元中的作用。受损伤的交感神经末梢通过α1和β肾上腺素能受体释放的去甲肾上腺素(NA)对KHEAT有抑制作用。结果提示,NA对KHEAT的抑制增强了神经元的兴奋性,导致神经病理性疼痛的产生。
英文摘要
To study the mechanism of generation of neuropathic pain, a role of a novel heat-activated K+ channel (Kheat) in dorsal root ganglion neurons was examined. Kheat was inhibited by noradrenaline (NA) that is released from injured sympathetic nerve terminals through both alpha1 and beta adrenergic receptors. From the result, it is suggested that inhibition of Kheat by NA increases the excitability of the neuron, leading to generation of neuropathic pain.
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DOI: 10.1186/1744-8069-7-41
发表时间: 2011-05-27
期刊: Molecular pain
影响因子: 3.3
作者: [Yoshida N, Kobayashi K, Yu L, Wang S, Na R, Yamamoto S, Noguchi K, Dai Y]
通讯作者: Dai Y
Chemical Composition of Disk Forming Regions of Solar-type Protostars and its Evolution to Planetary Systems
  • 批准号:
    18H05222
  • 项目类别:
    Grant-in-Aid for Scientific Research (S)
  • 资助金额:
    $120.22万
  • 财政年份:
    2018
  • 负责人:
    YAMAMOTO Satoshi
  • 依托单位:
Study of a role of serotonin on a novel K channel in neuropathic pain.
  • 批准号:
    16K09004
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2016
  • 负责人:
    YAMAMOTO Satoshi
  • 依托单位:
Study of a role of ATP on a novel K+ channel in neuropathic pain.
  • 批准号:
    25460731
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.33万
  • 财政年份:
    2013
  • 负责人:
    YAMAMOTO Satoshi
  • 依托单位:
Exploring Chemical Evolution from Star Forming Cores to Protoplanetary Disks by Multi-Wavelength Line Survey
  • 批准号:
    21224002
  • 项目类别:
    Grant-in-Aid for Scientific Research (S)
  • 资助金额:
    $109.16万
  • 财政年份:
    2009
  • 负责人:
    YAMAMOTO Satoshi
  • 依托单位:
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