Study of a role of sympathetic nerves on a novel K+ channel in neuropathic pain.
Study of a role of sympathetic nerves on a novel K+ channel in neuropathic pain.
批准号:
22600013
负责人:
YAMAMOTO Satoshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
为探讨神经病理性疼痛的发生机制,研究了一种新的热激活K+通道在背根神经节神经元中的作用。受损伤的交感神经末梢通过α1和β肾上腺素能受体释放的去甲肾上腺素(NA)对KHEAT有抑制作用。结果提示,NA对KHEAT的抑制增强了神经元的兴奋性,导致神经病理性疼痛的产生。
英文摘要
To study the mechanism of generation of neuropathic pain, a role of a novel heat-activated K+ channel (Kheat) in dorsal root ganglion neurons was examined. Kheat was inhibited by noradrenaline (NA) that is released from injured sympathetic nerve terminals through both alpha1 and beta adrenergic receptors. From the result, it is suggested that inhibition of Kheat by NA increases the excitability of the neuron, leading to generation of neuropathic pain.
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专著(0)
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会议论文
DOI:
10.1186/1744-8069-7-41
发表时间:
2011-05-27
期刊:
Molecular pain
影响因子:
3.3
作者:
[Yoshida N, Kobayashi K, Yu L, Wang S, Na R, Yamamoto S, Noguchi K, Dai Y]
通讯作者:
Dai Y
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资助金额:$120.22万
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财政年份:2018
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依托单位:
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项目类别:Grant-in-Aid for Scientific Research (C)
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Phase Interchange of Galactic Interstellar Gas Explored by the Terahertz Heterodyne Sensing
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依托单位:
A Large Scale Survey of the Subnmillimeter-wave Emission of Atomic Carbon at Northrn Chile
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依托单位:
Can apoptosis-suppressing proteins inhibit neuronal necrosis induced by brain ischemia?
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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依托单位:
Study on Molecular Cloud Formation by Large scale Submillimeter-wave Observations of Neutral Carbon Atom
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依托单位:
Role of glia cell during brain ischemia
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批准号:09680824
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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依托单位:
Precipitation of Lime Mud in Coral Reef Environments of the Ryukyu Arc
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批准号:08454144
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.33万
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负责人:YAMAMOTO Satoshi
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依托单位:
Development of carcinogenicity testing system using human skin xenografts transplanted to SCID mice and testing system for cancer chemopreventive agents
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批准号:06557144
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$7.23万
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依托单位:
Detection of New Interstellar Molecules by Fourier Transform Millimeter-wave Spectroscopy
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.8万
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依托单位:
Sedimentological study of sedimentation and dispersion processes of red soils in coastal areas of the Okinawa Island.
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批准号:04640712
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项目类别:Grant-in-Aid for General Scientific Research (C)
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依托单位:
Microwave Spectroscopy of Carbon-chain Molecules by Laser Evaporation
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资助金额:$1.28万
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依托单位:
Chemical Sedimentology of Pelagic Clay Minerals Contained in Pelagic Deep-Sea Cherts
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.9万
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负责人:YAMAMOTO Satoshi
-
依托单位:
海外基金