Visualization of chromosome aneuploidy in living embryo

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Chromosomal aneuploidy in oocyte and early embryo is major cause of early pregnancy loss and evokes severe chromosome disorder such as Down syndrome after birth. However, the mechanisms for the chromosome abnormality were still enigmatic due to the experimental limitations inherent to the early embryo. In this study, we established a new protocol to visualize the chromosomal aneuploidy in living embryo by developing the fluorescently probe that binds to the specific chromosomes.