Promotion of neuromuscular regeneration by transplantation of bone marrow and/ or muscle satellite cells

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Effects of transplantation of bone marrow and/ or muscle satellite cells with enhanced expression of heat shock protein 72(HSP72) on the regeneration of muscle and nerve were studied. These cells sampled from green mice were transplanted i. p. or i. v. through the jugular vein to mouse with hindlimb muscle injury caused by intramuscular injection of bupivacaine. The transplanted cells were detected in the injured muscle, not in the contralateral intact muscle. Effects of such treatment for promotion of regeneration were not clear due to the rejection of transplanted cells by the recipient mouse. However, it was suggested that beneficial effects of cell transplantation according to the analyses of morphological properties of muscle cross-section and gene expression.