Promotion of neuromuscular regeneration by transplantation of bone marrow and/ or muscle satellite cells

通过骨髓和/或肌肉卫星细胞移植促进神经肌肉再生

• 批准号: 22650153
• 负责人: OHIRA Yoshinobu
• 金额: $ 2.13万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650153/
• 关键词: 筋再生; 神経再生; サイトカイン; プロテオミクス; 温熱刺激; 筋活動; 脳機能; 感覚神経

Effects of transplantation of bone marrow and/ or muscle satellite cells with enhanced expression of heat shock protein 72(HSP72) on the regeneration of muscle and nerve were studied. These cells sampled from green mice were transplanted i. p. or i. v. through the jugular vein to mouse with hindlimb muscle injury caused by intramuscular injection of bupivacaine. The transplanted cells were detected in the injured muscle, not in the contralateral intact muscle. Effects of such treatment for promotion of regeneration were not clear due to the rejection of transplanted cells by the recipient mouse. However, it was suggested that beneficial effects of cell transplantation according to the analyses of morphological properties of muscle cross-section and gene expression.

研究了热休克蛋白72(HSP72)表达增强的骨髓和/或肌肉卫星细胞移植对肌肉和神经再生的影响。从绿色小鼠采集的这些细胞通过颈静脉或静脉移植到肌肉注射布比卡因造成后肢肌肉损伤的小鼠身上。移植细胞在损伤侧肌肉中检测到，而在健侧肌肉中未检测到。由于受体小鼠对移植细胞的排斥，这种处理促进再生的效果尚不清楚。然而，根据对肌肉横截面的形态特征和基因表达的分析，认为细胞移植的有益效果。

项目成果

Long-term exposure to real and simulated microgravity depresses the number of epididymal sperm in mice

长期暴露于真实和模拟的微重力会抑制小鼠附睾精子的数量

• 发表时间: 2011
• 作者: Shibaguchi;T.;et al.
• 通讯作者: et al.

Effects of 3-month spaceflight on the characteristics of neck muscle in mice

3个月太空飞行对小鼠颈部肌肉特征的影响

• 发表时间: 2011
• 作者: Ohira;T.
• 通讯作者: T.

A possible role of NF-К_B and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats

NF-К_B和HSP72在热应激诱导大鼠骨骼肌肥大中的可能作用

• 发表时间: 2010
• 期刊: Gen. Physiol. Biophys
• 作者: Ohno;Y.;S. Yamada;T. Sugiura;Y. Ohira;T. Yoshioka;and K. Goto
• 通讯作者: and K. Goto

骨格筋の再生と再成長における荷重とミオスタチンの影響

负荷和肌生长抑制素对骨骼肌再生和再生长的影响

• 发表时间: 2010
• 作者: 後藤勝正;杉浦崇夫;大平充宣;吉岡利忠
• 通讯作者: 吉岡利忠

Possible role of NF-. B signals in heat stress-associated increase in protein content of cultured C2C12 cells

NF-的可能作用。

• 发表时间: 2011
• 期刊: Cells Tissues Organs
• 影响因子: 2.7
• 作者: Ohno;Y.;S. Yamada;T. Sugiura;Y. Ohira;T. Yoshioka;and K. Goto
• 通讯作者: and K. Goto