Promotion of muscle activities as the countermeasure for prevention of the deterioration of brain function

促进肌肉活动作为预防脑功能恶化的对策

• 批准号: 19100009
• 负责人: OHIRA Yoshinobu
• 金额: $ 74.46万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19100009/
• 关键词: 筋活動; 脳機能; 感覚神経; プロテオミクス; 筋再生; 骨格筋; 脳; プロテオーム; 遺伝子; 再生

Effects of antigravity muscle activity on the function and/ or protein expression in rat brain were studied. Since the muscle injury inhibits the physical activity, the study was also performed to investigate the suitable methods for promotion of regeneration of injured muscle. As the results, inhibition of hindlimb muscle activity by gravitational unloading caused detrimental effects on the normal growth and development of brain in new-born rats. Further, application of heat stress to injured muscles promoted the regeneration. In these muscles, cells expressing heat shock protein 72(HSP72) were observed in capillary vessels, not in muscle fibers. These cells were either bone marrow cells or neutrophils. The data indicated that HSP72 plays some indirect roles for stimulation of muscle regeneration. Heat-stress-specific changes in gene and protein expression were also observed.

研究了抗重力肌活动对大鼠脑功能和/或蛋白质表达的影响。由于肌肉损伤抑制了身体活动，因此还进行了研究以研究促进损伤肌肉再生的合适方法。结果表明，重力去负荷对新生大鼠后肢肌肉活动的抑制，对新生大鼠脑的正常生长发育产生不利影响。此外，对损伤的肌肉施加热应激促进了再生。在这些肌肉中，在毛细血管中观察到表达热休克蛋白72（HSP 72）的细胞，而不是在肌纤维中。这些细胞是骨髓细胞或中性粒细胞。提示HSP 72在促进肌肉再生中起间接作用。还观察到基因和蛋白质表达的热应激特异性变化。

项目成果

宇宙環境暴露および老化による骨格筋の萎縮

由于太空环境暴露和老化导致骨骼肌萎缩

• 发表时间: 2007
• 期刊: 宇宙航空環境医学 44
• 作者: Goto;K.;後藤 勝正;後藤 勝正
• 通讯作者: 後藤 勝正

Role(s) of nucleoli and phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass

• DOI: 10.1152/ajpcell.00297.2006
• 发表时间: 2007-07-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
• 影响因子: 5.5
• 作者: Kawano, F.;Matsuoka, Y.;Ohira, Y.
• 通讯作者: Ohira, Y.

Control of muscle protein synthesis in response to exercise and amino acids

根据运动和氨基酸控制肌肉蛋白质合成

• 发表时间: 2012
• 期刊: J. Phys. Fit. Sports Med.
• 作者: Nakai;N.
• 通讯作者: N.

Effects of hindlimb unloading on neurogenesis in the hippocampus of newly weaned rats

• DOI: 10.1016/j.neulet.2011.12.022
• 发表时间: 2012-02-16
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Nomura, Sachiko;Kami, Katsuya;Ohira, Yoshinobu
• 通讯作者: Ohira, Yoshinobu

3ヶ月の宇宙基地滞在がマウスの生理学的特性に及ぼす影響:宇宙実験のコントロールとしての地上シミュレーション実験

空间站停留3个月对小鼠生理特征的影响：地面模拟实验作为空间实验的对照

• 发表时间: 2011
• 作者: Safari;F.;Murata-Kamiya;N.;Saito;Y. andHatakeyama;M.;大平充宣
• 通讯作者: 大平充宣