Promotion of muscle activities as the countermeasure for prevention of the deterioration of brain function

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Effects of antigravity muscle activity on the function and/ or protein expression in rat brain were studied. Since the muscle injury inhibits the physical activity, the study was also performed to investigate the suitable methods for promotion of regeneration of injured muscle. As the results, inhibition of hindlimb muscle activity by gravitational unloading caused detrimental effects on the normal growth and development of brain in new-born rats. Further, application of heat stress to injured muscles promoted the regeneration. In these muscles, cells expressing heat shock protein 72(HSP72) were observed in capillary vessels, not in muscle fibers. These cells were either bone marrow cells or neutrophils. The data indicated that HSP72 plays some indirect roles for stimulation of muscle regeneration. Heat-stress-specific changes in gene and protein expression were also observed.