The role of gut bacterial flora in the development of sarcopenia

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In order to clarify whether sarcopenia associated with ageing depends upon gut function maintained by gut flora, we investigated the effect of antibiotics treatment, by which majority of gut flora was eliminated, on the process of skeletal muscle damage and recovery and the process of skeletal muscle disuse atrophy and its recovery after reloading. We found that bacterial elimination resulted in a significant delay in the process of skeletal muscle recovery from disuse atrophy. In a separate experiment, we found that unlike LPS, peptide glycan (PGN)administration to antibiotics treated mice was not as effective in reversing the delayed recovery from chemically induced muscle damage.