Metabolic regulation through the mechanotransduction pathway

通过力传导途径的代谢调节

• 批准号: 22657046
• 负责人: OGURA Toshihiko
• 金额: $ 2.19万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22657046/
• 关键词: 力学刺激; 運動; 心臓; 筋肉; ATP

In this project, we have found two force-sensitive metabolic regulators. One of them is localized in the adhesion complexes. When cells are stretched, this factor shuttles from the cytoplasm to the nucleus to regulate adipogenic differentiation of stem cells. Another metabolic regulator also shuttles into the nucleus in response to hemodynamic forces to activate nuclear orphan receptors and increase ATP production in heart, hence activate an essential adaptive responses of cardiomyocytes to hemodynamic overload Our data provide novel targets of metabolic regulation.

在这个项目中，我们发现了两个力敏感的代谢调节因子。其中一个定位于黏附复合体中。当细胞被拉伸时，这种因子从细胞质穿梭到细胞核，调节干细胞的成脂分化。另一种代谢调节因子也穿梭到细胞核内，以响应血流动力学的力量，激活核孤儿受体，增加心脏中ATP的产生，从而激活心肌细胞对血流动力学超负荷的必要适应性反应。我们的研究为代谢调节提供了新的靶点。

项目成果

Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II

• DOI: 10.1242/dev.050120
• 发表时间: 2010-09-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Hirota, Yuki;Meunier, Alice;Sawamoto, Kazunobu
• 通讯作者: Sawamoto, Kazunobu

Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin

多纤毛室管膜细胞的平面极性涉及非肌肉肌球蛋白调节的基体向前迁移

• 发表时间: 2010
• 期刊: Development
• 影响因子: 4.6
• 作者: Hirota Y.;et al
• 通讯作者: et al

Expression and Proliferation‐Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain

Diversin 在成年小鼠大脑中神经元定向前体细胞迁移中的表达和增殖促进作用

• DOI: 10.1002/stem.516
• 发表时间: 2010
• 期刊: STEM CELLS
• 影响因子: 5.2
• 作者: Makiko Ikeda;Yuki Hirota;M. Sakaguchi;Osamu Yamada;Yasuyuki S. Kida;T. Ogura;T. Otsuka;H. Okano;K. Sawamoto
• 通讯作者: K. Sawamoto

Hemodynamic force is a Physical regulator of cardiac valvulogensis

血流动力是心脏瓣膜形成的物理调节剂

• 发表时间: 2011
• 作者: Takamasa Mizoguchi;Satoshi Togawa;Koichi Kawakami and Motoyuki Itoh;小椋利彦
• 通讯作者: 小椋利彦

Gene manipulation of chick embryos in vitro, EC culture, and long survival in transplanted eggs.

鸡胚胎体外基因操作、EC 培养和移植卵的长期存活。

• 发表时间: 2010
• 期刊: Development, Growth & Differentiation
• 作者: Tanaka J.;et al
• 通讯作者: et al