Metabolic regulation through the mechanotransduction pathway

在这个项目中，我们发现了两个力敏代谢调节因子。其中之一是本地化的粘附复合物。当细胞被拉伸时，该因子从细胞质穿梭到细胞核以调节干细胞的成脂分化。另一种代谢调节因子也在血流动力学的作用下穿梭进入细胞核，激活核孤儿受体，增加心肌ATP的产生，从而激活心肌细胞对血流动力学过载的适应性反应。我们的数据提供了新的代谢调节靶点。

In this project, we have found two force-sensitive metabolic regulators. One of them is localized in the adhesion complexes. When cells are stretched, this factor shuttles from the cytoplasm to the nucleus to regulate adipogenic differentiation of stem cells. Another metabolic regulator also shuttles into the nucleus in response to hemodynamic forces to activate nuclear orphan receptors and increase ATP production in heart, hence activate an essential adaptive responses of cardiomyocytes to hemodynamic overload Our data provide novel targets of metabolic regulation.