Basic study to understand "molecular mimicry" of the host by parasitic wasp embryos

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A polyembryonic wasp Copidosoma floridanum embryo compatitibly invades the host embryo. This suggests that the host embryonic cells recognize the invading wasp embryo by molecules on the cell surface. Here we developed an in vitro wasp entry inhibition assay and found that E-cadherin and C-type lectins of the wasp embryo were involved in their invasion into the host embryo. The molecular characterization of C. floridanum E-cadherin and related molecules associated with the extracellular matrix were also analysed.