Development of functional analysis of secretory lysosomes
Development of functional analysis of secretory lysosomes
批准号:
22658036
负责人:
KATAOKA Takao
金额:
$2.2万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Lysosomes are Organelles essential for the degradation of biological components, and contain soluble acid hydrolases as well as lysosomal membrane proteins.Secretory lysosomes referred to as lytic granules are present in cytotoxic T lymphocytes and natural killer cells. In this study novel molecular probes using lysosomal membrane proteins were constructed for the visualization and purification of secretory lysosomes such as lytic granules and the intracellular localization of these molecular probes on various types of cells was analyzed.
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TNF レセプター1 のシグナル伝達経路に対するタンパク質合成阻害剤の作用機序の解析
蛋白质合成抑制剂对TNF受体1信号转导通路的作用机制分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[千本木淳子, ら, 平野誠也(片岡孝夫)]
通讯作者:
平野誠也(片岡孝夫)
T-box 転写因子T-betおよびeomesodermin のサイトカイン産生誘導における作用機序の解析
T-box转录因子T-bet和eomesodermin诱导细胞因子产生的作用机制分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Masaru Enomoto, Shigefumi Kuwahara, Tuan Thanh Chau, 宮本皓司他 8 名, 廣川高史,山真将,桑原重文, 西田愛(片岡孝夫)]
通讯作者:
西田愛(片岡孝夫)
転写因子NF-κBの活性化におけるカスパーゼ8とその調節因子c-FLIPの機能解析
Caspase 8及其调节因子c-FLIP在转录因子NF-κB激活中的功能分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Masaru Enomoto, Shigefumi Kuwahara, Tuan Thanh Chau, 宮本皓司他 8 名, 廣川高史,山真将,桑原重文, 西田愛(片岡孝夫), 宮本皓司, 松下由果(片岡孝夫), 宮本皓司, 藤田聡美,渡邊麻衣,廣川高史,榎本賢,桑原重文, 知念拓実, 鈴木智美,永沢友裕,榎本賢,桑原重文, 小川哲史, 廣川高史,陰山真将,桑原重文, 西田愛, 岡田憲典, 永沢友裕,桑原重文, 松下由果]
通讯作者:
松下由果
Ursolic acid inhibits Na^+/^+-ATPase activity and prevents TNF-α-induced gene expression by blocking amino acid transport and cellular protein synthesis
熊果酸通过阻断氨基酸转运和细胞蛋白质合成来抑制 Na^+/^+-ATPase 活性并防止 TNF-α 诱导的基因表达
DOI:
--
发表时间:
2011
期刊:
Biomolecules
影响因子:
5.5
作者:
[Saki Gotoh , Takayuki Nakamura , Takao Kataoka , Shigeru Taketani, Yoshiko Ohgari, Tomonobu Yokomichi]
通讯作者:
Tomonobu Yokomichi
炎症性サイトカインによる細胞接着因子ICAM-1の発現誘導に対するウルソール酸の作用機序の解析
熊果酸通过炎症细胞因子诱导细胞粘附因子ICAM-1表达的作用机制分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yoshinaga N, Abe H, Morita S, Yoshida T, Aboshi T, Fukui M, Tumlinson JH, Mori N., 横道公伸]
通讯作者:
横道公伸
共 40 条
Construction of membrane-bound hybrid molecules for analyzing cytotoxic granules
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批准号:21K19080
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$3.99万
-
财政年份:2021
-
负责人:KATAOKA Takao
-
依托单位:
Elucidation of molecular mechanisms of bioprobes on signaling pathways of inflammatory responses and hypoxic responses
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批准号:16H04910
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.32万
-
财政年份:2016
-
负责人:KATAOKA Takao
-
依托单位:
Molecular mechanisms of signaling pathways regulating inflammatory responses and their elucidation by bioprobes
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批准号:25292061
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
-
财政年份:2013
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负责人:KATAOKA Takao
-
依托单位:
Molecular mechanism of inflammatory cytokine signaling and its regulation by bioprobes
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批准号:22380060
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.48万
-
财政年份:2010
-
负责人:KATAOKA Takao
-
依托单位:
Molecular mechanism and bioprobes of cytokine receptor signaling
-
批准号:19380057
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.81万
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财政年份:2007
-
负责人:KATAOKA Takao
-
依托单位:
Analysis of molecular mechanism of signal transduction pathway via cytokine receptors by bioprobes
-
批准号:15380069
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.55万
-
财政年份:2003
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负责人:KATAOKA Takao
-
依托单位:
Analysis of the signal transduction pathway of the transcription factor NF-κB activated by cytokines
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批准号:13660083
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:2001
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负责人:KATAOKA Takao
-
依托单位:
Analysis of apoptosis induction and NF-κB activation mediated by death receptors
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批准号:11660077
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:KATAOKA Takao
-
依托单位:
海外基金