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Synthesis and Application of Binding-typed Inhibitor for Infection of Influenza Virus on a Base of New Conception

Synthesis and Application of Binding-typed Inhibitor for Infection of Influenza Virus on a Base of New Conception
新概念流感病毒感染结合型抑制剂的合成及应用
批准号:
22658035
负责人:
YAMAMOTO Kenji
金额:
$2.28万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
翻译
我们已经成功地简单合成了流感病毒的有效结合抑制剂,这些抑制剂是由从蛋黄中提取的糖肽的唾液醛糖组成的。采用缩合反应和还原性胺化反应分别对海藻酸盐和壳聚糖进行了改性。这些结合抑制剂利用流感病毒的碳水化合物识别唾液酸,因此它们可以防止病毒感染。所得到的抑制剂对MDCK细胞的流感病毒感染表现出足够的抑制活性。与其他流感病毒结合抑制剂不同,这些病毒抑制剂的合成步骤简单。
英文摘要
We have succeeded in simple syntheses of efficient binding-inhibitors for influenza virus, which are composed of sialyl saccharides of glycopeptides extracted from hen egg yolk. We modified alginate and chitosan with multiple sialyl saccharides using condensation reaction and reductive amination reaction, respectively. These binding-inhibitors utilize the carbohydrate recognition of influenza virus for sialic acid, thus they can prevent the virus from infection. The resulting inhibitors showed sufficient inhibitory activity against influenza virus infection in MDCK cells. Unlike the other binding-inhibitors of influenza virus, these virus inhibitors require simple step in their syntheses.
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会议论文
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  • 批准号:
    16K10260
  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 批准号:
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  • 项目类别:
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  • 财政年份:
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  • 批准号:
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  • 项目类别:
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海外基金