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Synthesis and Application of Binding-typed Inhibitor for Infection of Influenza Virus on a Base of New Conception

Synthesis and Application of Binding-typed Inhibitor for Infection of Influenza Virus on a Base of New Conception
新概念流感病毒感染结合型抑制剂的合成及应用
批准号：
22658035
负责人：
YAMAMOTO Kenji
金额：
$2.28万
依托单位：
Ishikawa Prefectural University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22658035/
关键词：
インフルエンザウイルス感染阻害剤シアロ糖鎖アルギン酸キトサンインフルエンザウィルスシアリルラクトースMDCK細胞エンド-Mシアロ糖鎖ポリマー免疫蛍光抗体法

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英文摘要
We have succeeded in simple syntheses of efficient binding-inhibitors for influenza virus, which are composed of sialyl saccharides of glycopeptides extracted from hen egg yolk. We modified alginate and chitosan with multiple sialyl saccharides using condensation reaction and reductive amination reaction, respectively. These binding-inhibitors utilize the carbohydrate recognition of influenza virus for sialic acid, thus they can prevent the virus from infection. The resulting inhibitors showed sufficient inhibitory activity against influenza virus infection in MDCK cells. Unlike the other binding-inhibitors of influenza virus, these virus inhibitors require simple step in their syntheses.
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