Single-neuron analysis of strain recognition memory in mice

我们研究了mGluR2（一种代谢性谷氨酸受体）的药理和遗传操作对副嗅球（AOB）薄片二尖瓣或颗粒细胞突触电流的影响，副嗅球是小鼠配偶识别记忆的关键部位。结果表明，mGluR2通过抑制AOB中二尖瓣细胞向颗粒细胞的兴奋传递来降低二尖瓣细胞的树突抑制。我们目前正在进行一项实验，以表征储存配偶识别记忆的二尖瓣细胞和颗粒细胞的特性。

We examined the effects of pharmacological and genetic manipulations of mGluR2, a metabotropic glutamate receptor, on synaptic currents measured from mitral or granule cells in slices of the accessory olfactory bulb(AOB), which is a critical site for mate recognition memory in mice. The results indicate that mGluR2 reduces dendrodendritic inhibition of mitral cells by inhibiting excitatory transmission from mitral cells to granule cells in the AOB. We are currently undertaking an experiment to characterize the properties of mitral and granule cells that store the mate recognition memory.