Molecular mechanisms of dynamic changes in memory traces
记忆痕迹动态变化的分子机制
基本信息
- 批准号:16300100
- 负责人:
- 金额:$ 9.54万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2006
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
When a female is mated with a male partner, she forms a memory to the urinary pheromones of the male, thereby preventing his pheromones from inducing pregnancy block. The neural changes underlying this memory occur in the accessory olfactory bulb (AOB), the first relay in the vomeronasal system, depend upon mating-induced enhancement of alpha2-adrenergic transmission in the AOB and involve changes at the reciprocal synapses between mitral and granule cells. In this study, we demonstrate that oxytocin facilitates the induction of long-term potentiation at the mitral-to-granule cell synapse.We have established a procedure for the co-culture of vomeronasal sensory neurons (VSNs) with AOB neurons. Our data suggest that the differentiation and/or maturation of VSNs and AOB neurons are both stimulated or modified by the co-culture. By examining the expression of V2R-type vomeronasal receptors (VR1 and VR2) and chemosensory responsiveness in the vomeronasal organ cocultured with AOB neurons, we demonstrate that AOB neurons induce the expression of vomeronasal receptors in VSNs, allowing them to function.On postnatal day 12, young rats show an aversion to an odour to which they had been exposed along with presentations of foot shock on postnatal day 11. By infusing the protein phosphatase 1 (PP1) inhibitor, inhibitor-2 into the olfactory bulb (OB) during odour-shock training, we demonstrate that PP1 is involved in the extinction process of aversive olfactory learning. We have shown that cyclic AMP response element binding protein (CREB) and its phosphorylation in the OB are required for the long-term, but not the short-term, facilitation process of this olfactory learning. CREB phosphorylation has been shown to induce histone acetylation. In this study, we demonstrate that histone acetylation in the OB is involved in the acquisition process of this olfactory learning.
当雌性与雄性交配时,雌性会对雄性的尿信息素形成记忆,从而阻止雄性的信息素引起的妊娠阻滞。这种记忆背后的神经变化发生在副嗅球(AOB)中,它是粪鼻系统中的第一个中继,依赖于交配诱导的AOB中α 2-肾上腺素能传递的增强,并涉及二尖瓣细胞和颗粒细胞之间的互惠突触的变化。在这项研究中,我们证明了催产素促进二尖瓣到颗粒细胞突触的长期增强。我们建立了犁鼻感觉神经元(VSNs)与AOB神经元共培养的方法。我们的数据表明,VSNs和AOB神经元的分化和/或成熟都受到共培养的刺激或修饰。通过检测与AOB神经元共培养的犁鼻器官中v2r型犁鼻受体(VR1和VR2)的表达和化学感觉反应,我们证明AOB神经元诱导VSNs中犁鼻受体的表达,使其发挥功能。在出生后的第12天,幼鼠对暴露在气味中的气味表现出厌恶,并在出生后的第11天出现足部休克。通过将蛋白磷酸酶1 (PP1)抑制剂、抑制剂-2注入嗅球(OB)进行气味休克训练,我们证明了PP1参与了厌恶嗅觉学习的消退过程。我们已经证明,环AMP反应元件结合蛋白(CREB)及其在OB中的磷酸化对于这种嗅觉学习的长期促进过程是必需的,而不是短期的。CREB磷酸化已被证明可诱导组蛋白乙酰化。在这项研究中,我们证明OB中的组蛋白乙酰化参与了这种嗅觉学习的习得过程。
项目成果
期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Encyclopedia of Neuroscience
- DOI:10.1016/b978-008045046-9.01140-2
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:A. Grace;D. Lodge;D. Buffalari
- 通讯作者:A. Grace;D. Lodge;D. Buffalari
Functional synapse formation between cultured rat accessory olfactory bulb neurons and vomeronasal pockets
培养的大鼠辅助嗅球神经元和犁鼻袋之间功能性突触的形成
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Muramoto;K.;et al.
- 通讯作者:et al.
Long-term potentiation in the accessory olfactory bulb: A mechanism for olfactory learning
- DOI:10.1093/chemse/bjh158
- 发表时间:2005-01-01
- 期刊:
- 影响因子:3.5
- 作者:Kaba, H;Huang, GZ
- 通讯作者:Huang, GZ
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{{ truncateString('KABA Hideto', 18)}}的其他基金
Do mitochondrially encoded peptides function as strain identity chemosignals in mice?
线粒体编码的肽是否可以作为小鼠品系识别化学信号?
- 批准号:
17K19635 - 财政年份:2017
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Common mechanisms of synaptic plasticity underling olfactory bonds
嗅觉键下突触可塑性的常见机制
- 批准号:
26293047 - 财政年份:2014
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of mechanisms underlying strain recognition memory in mice using visualization techniques
使用可视化技术分析小鼠应变识别记忆的机制
- 批准号:
24659108 - 财政年份:2012
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Neurobiological mechanisms underlying olfactory bonds
嗅觉联系背后的神经生物学机制
- 批准号:
23390050 - 财政年份:2011
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Single-neuron analysis of strain recognition memory in mice
小鼠应变识别记忆的单神经元分析
- 批准号:
22659049 - 财政年份:2010
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Mechanisms of formation, maintenance and extinction of olfactory learning
嗅觉学习的形成、维持和消退机制
- 批准号:
13480268 - 财政年份:2001
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of mechanisms of pheromonal memory formation
信息素记忆形成机制分析
- 批准号:
10460133 - 财政年份:1998
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Molecular mechanisms of an olfactory memory relevant to species survival
与物种生存相关的嗅觉记忆的分子机制
- 批准号:
08456154 - 财政年份:1996
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular and Sellular Mechanisms Underlying an Olfactory Memory in the Context of Pregnancy Block
妊娠阻滞背景下嗅觉记忆的分子和细胞机制
- 批准号:
01570087 - 财政年份:1989
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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