An exploration of causative genes of focal cortical dysplasia with intractable epilepsy, using advanced technologies

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Intractable epilepsy in childhood has other problems and leads to be difficult to spend daily ability. The major cause of the epilepsy is focal cortical dysplasia (FCD), which shows characteristic dysplasia in a part of cerebral cortex. In the present study, we explore causative genes of FCD formation, using cell sorting technique and CGH （Comparative genomic hybridization）array analysis. We used DNA samples of 4 FCD patients, whose parents agreed with the research usage under an informed consent. As a result, we obtained no 4-patient common abnormal gene, two 3-patient common abnormal genes and thirteen 2-patient common abnormal genes. Among them, we could pick up six genes for the candidates. We advance further analyses for the goal.