Molecular imaging for the evaluation of chemosensitivity by a novel hyperpolarized magnetic resonance imaging

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We investigated the pre-clinical tests for the introduction of NMR-SABRE, a novel hyperpolarized nuclear magnetic resonance technique. One was the evaluation of the safety of hyperpolarized probes. In this study, we searched for safe alternative solvents and catalysts instead of materials that are currently used in basic researches. The other was the development of methods for in vivo prediction of chemosensitivity in animal tumor models. In this study, we suggested the usefulness of the quantification of total choline and diffusion index. The evaluation methods of 5-FU, an anticancer drug, and its cytotoxic metabolite were also studied using NMR technique.