The imaging of micrometastases in lymph nodes by super-high-resolution magnetic resonance imaging in combination with super-high-sensitivity imaging.

超高分辨率磁共振成像结合超高灵敏度成像对淋巴结微转移进行成像。

• 批准号: 19591446
• 负责人: FUJII Hirofumi
• 金额: $ 2.83万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591446/
• 关键词: 画像診断学(含放射線診断学、核医学); SPECT; Tc-99m; MRI; 融合画像; リンパ節; 転移

In this study, diagnostic imaging methods to visualize micrometastases in lymph nodes were studied using mouse models. A common bed that can be used in both SPECT and MRI was made. After Tc-99m phytate was injected into mouse footpads, the mouse was fixed on the common bed. Then, lymphoscintigraphy was obtained using a SPECT/CT scanner dedicated for small animals and sentinel lymph nodes were identified. After that, the mouse that was fixed on the common bed was moved to an MRI system that was composed of a 3.0T clinical MRI scanner and a coil dedicated for mice. The interior of the identified sentinel lymph node was observed by high resolution MR images. Our common bed successfully enabled to fuse SPECT images and high-resolution MR images with the gap less than 1mm. As a result, the interiors of sentinel lymph nodes that were identified with high sensitivity by Tc-99m phytate SPECT could be precisely observed by high resolution MR images.

在这项研究中，使用小鼠模型研究了可视化淋巴结微转移的诊断成像方法。研制了一种SPECT和MRI共用床。将Tc-99 m植酸盐注射到小鼠足垫后，将小鼠固定在普通床上。然后，使用专用于小动物的SPECT/CT扫描仪获得淋巴结造影，并识别前哨淋巴结。然后，将固定在普通床上的小鼠移到由3.0T临床MRI扫描仪和小鼠专用线圈组成的MRI系统上。通过高分辨率MR图像观察所识别的前哨淋巴结内部。我们的普通床成功地实现了SPECT图像和高分辨率MR图像的融合，差距小于1 mm。因此，通过Tc-99 m植酸盐SPECT以高灵敏度识别的前哨淋巴结的内部可以通过高分辨率MR图像精确地观察。

项目成果

Image processing to clearly visualize both sentinel lymph nodes and body silhouette on the lymphoscintigram

图像处理可在淋巴闪烁图上清晰地显示前哨淋巴结和身体轮廓

• 发表时间: 2009
• 作者: Fujii H;Ikeda T;Kitagawa Y;Suzuki C;Nakahara T;Ando Y;Kitajima M;Kubo A
• 通讯作者: Kubo A

Validation Study of Radio-Guided Sentinel Lymph Node Navigation in Esophageal Cancer

• DOI: 10.1097/sla.0b013e3181a38e89
• 发表时间: 2009-05-01
• 期刊: ANNALS OF SURGERY
• 影响因子: 9
• 作者: Takeuchi, Hiroya;Fujii, Hirofumi;Kitagawa, Yuko
• 通讯作者: Kitagawa, Yuko

SPECT技術を用いた小動物イメージング

使用 SPECT 技术的小动物成像

• 发表时间: 2008
• 期刊: RADIOISOTOPES 57巻
• 作者: 藤井博史;梅田泉;小島良紀
• 通讯作者: 小島良紀

核医学+αの融合画像を目指して

瞄准核医学融合图像+α

• 发表时间: 2007
• 作者: 藤森弘貴;藤井博史;藤井博史;藤井博史;藤井博史
• 通讯作者: 藤井博史

小動物の生理機能を in vivo で観る

观察小动物体内生理功能

• 发表时间: 2008
• 期刊: Isotope News 652
• 作者: 梅田泉;藤井博史
• 通讯作者: 藤井博史