Fusion imaging for sentinel node navigation high-precision radiotherapy

前哨淋巴结导航高精度放疗融合成像

• 批准号: 22390240
• 负责人: FUJII Hirofumi
• 金额: $ 11.56万
• 依托单位: National Cancer Center Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390240/
• 关键词: 核医学; センチネルリンパ節; 高精度放射線治療; 融合画像; SPECT

This study was aimed to develop the least invasive therapeutic methods to cure early-stage cancer. We tried to visualize the metastatic status of sentinel lymph nodes that are the first nodes involved by cancer and conditions of tumor interiors such as hypoxia and the expression of integrin in vivo by using nuclear medicine images, magnetic resonance images and their fusion images. We also developed spot scanning irradiation methods by pencil beams in proton beam therapy so that the optimized therapy would be performed according to the findings of functional imaging tests.

本研究旨在开发微创治疗早期癌症的方法。我们试图通过核医学图像、磁共振图像及其融合图像来可视化前哨淋巴结的转移状态，以及肿瘤内部缺氧和体内整合素表达等情况。前哨淋巴结是癌症涉及的第一个淋巴结。我们还开发了质子束治疗中的铅笔束点扫描照射方法，以便根据功能成像检查结果进行优化治疗。

项目成果

SPECT-MRI co-registration for lymph node imaging : a feasibility study using a lymphadenitis animal model

SPECT-MRI 淋巴结成像联合配准：使用淋巴结炎动物模型的可行性研究

• 发表时间: 2010
• 作者: Suzuki D;Fujii H;et al
• 通讯作者: et al

Interstitial MR lymphangiography in the head and neck region using superparamagnetic iron oxides and gadoxetate sodium -preliminary animal study.

使用超顺磁性氧化铁和钆塞酸钠在头颈部进行间质 MR 淋巴管造影 - 初步动物研究。

• 发表时间: 2010
• 作者: Kitamura N;Araki K;Kosuda S;Tomifuji M;Shiotani A;Shigematsu N;Fujii H
• 通讯作者: Fujii H

Pitfalls of SPIO-enhanced MR Lymphography in Sentinel Lymph Nodes: Pathogenesis of High Signals Mimicking Metastasis in Inflamed Lymph Nodes.

SPIO 增强 MR 淋巴成像在前哨淋巴结中的缺陷：模拟发炎淋巴结转移的高信号的发病机制。

• 发表时间: 2012
• 作者: Suzuki D;Yamaguchi M;Furuta T;Nakagami R;Okuyama Y;Yoshikawa K;Fujii H
• 通讯作者: Fujii H

The detection of small LN metastases using radiocolloids.

使用放射性胶体检测小淋巴结转移。

• 发表时间: 2010
• 作者: Aodai T;Masuzawa T;Ozeki K;Kishida A;and Higami T;Fujii H
• 通讯作者: Fujii H

A novel PET probe for tumor hypoxia imaging with excellent renal clearance.

一种用于肿瘤缺氧成像的新型 PET 探针，具有出色的肾清除率。

• 发表时间: 2012
• 作者: Kimura S;Kuriyama T;Kojima YK;Umeda IO;Moriyama N;Fujii H
• 通讯作者: Fujii H