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Three-dimensional fusion imaging of radioscintigraphy and CT for minimal invasive treatment of malignancies.

放射闪烁扫描和 CT 的三维融合成像用于恶性肿瘤的微创治疗。

基本信息

批准号：
15591303
负责人：
FUJII Hirofumi
金额：
$ 1.79万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591303/
关键词：
Sentinel node Body contour Fusion imaging センチネルリンパ説

项目摘要

In the first year, we engaged to investigate the visualization of body contours for the fusion of radio-scintigrams and CT images. We applied to the acquisition method using the double energy windows where the scattered photons with lower energy produced by Comp ton scattering are used to visualize the body contours. In SPECT imaging, additional external sources were used to enhance the scattered photons. When syringes with 1ml of Tc-99m (37MBq) were put at the edge of each detector of SPECT camera and images were acquired with 12 degree step of 30 seconds, the body contour clear enough to apply fusion of images could be obtained.These scintigrams were merged to CT images on workstation (GMS-5500A/PI, Toshiba, Tokyo) using ART (automatic registration tool) and merged images could show the clear identification of the anatomical location of SLN. The gaps between the LN image on the CT and hot spot on scintigrams were clinically acceptable.In the second year, we engaged in coded aperture imaging to improve the sensitivity of 3D scintigraphic imaging. Coded aperture can provide more excellent sensitivity than parallel-hole collimator keeping as good spatial resolution as pinhole collimator, resulting in the shorter acquisition time in the intra-operative imaging. We could obtain the combination of parameters that show the best sensitivity and the best spatial resolution.

在第一年，我们致力于研究身体轮廓的可视化，以融合放射线断层摄影和CT图像。我们应用于使用双能量窗口的采集方法，其中由康普顿散射产生的具有较低能量的散射光子用于可视化身体轮廓。在SPECT成像中，使用额外的外部源来增强散射光子。将装有1 ml Tc-99 m（37 MBq）的注射器置于SPECT相机每个探测器的边缘，以30秒的12度步进获取图像，即可获得足够清晰的身体轮廓以进行图像融合。将这些闪烁图与工作站上的CT图像合并。（GMS-5500 A/PI，Toshiba，Tokyo）使用ART（自动配准工具）和合并图像可以显示SLN解剖位置的清晰识别。第二年，我们采用编码孔径成像技术，以提高三维CT成像的灵敏度。编码孔径可以提供比平行孔准直器更好的灵敏度，同时保持针孔准直器良好的空间分辨率，从而缩短术中成像的采集时间。我们可以获得显示最佳灵敏度和最佳空间分辨率的参数组合。