Analysis of pathophysiology of presbycusis by gene profile study of senescent cochlear cells
Analysis of pathophysiology of presbycusis by gene profile study of senescent cochlear cells
批准号:
22659305
负责人:
KITAMURA Ken
金额:
$2.1万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
耳蜗免疫组化研究显示,90岁以上人群耳蜗基底部螺旋韧带阳性面积率高于65 ~ 75岁人群。采用激光显微解剖方法,成功地从档案福尔马林固定石蜡包埋的人耳蜗细胞中提取了COCH和SLC26A5 mRNA。
英文摘要
Immunohistochemical study of cochlin demonstrated increased rate of positive area in the spiral ligament of the basal turn of the cochlea of the subjects at the age of older than 90 years than that of the age from 65 to 75 years. We succeeded to extract mRNA of COCH and SLC26A5 from archival formalin fixed paraffin embedded human cochlear cells by laser microdissection.
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The certain etiology of the superior canal dehiscence syndrome : does human evolution cause vertigo?
上半管裂综合征的确定病因:人类进化导致眩晕吗?
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tsunoda A, Kitamura K, Takahashi N, Akita K, Yamaguchi K]
通讯作者:
Yamaguchi K
言語聴覚士のための聴覚障害学
言语病理学家的听力障碍研究
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tagaya M, Teranishi M, Naganawa S, Iwata T, Yoshida T, Otake H, Nakata S, Sone M, Nakashima T., 喜多村 健]
通讯作者:
喜多村 健
Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss.
对遗传性听力损失患者的主要线粒体 DNA 点突变进行扩展筛查。
DOI:
10.1038/jhg.2012.109
发表时间:
2012
期刊:
J Hum Genet
影响因子:
3.5
作者:
[Kato T, Nishigaki Y, Noguchi Y, Fuku N, Ito T, Mikami E, Kitamura K, Tanaka M.]
通讯作者:
Tanaka M.
Quantitative cellular love] analysis of mitochondrial DNA 3243A>G mutations in individual tissues from the archival temporal bones of a MELAS patient
定量细胞之爱]MELAS 患者档案颞骨个体组织中线粒体 DNA 3243A>G 突变分析
DOI:
--
发表时间:
2010
期刊:
Acta Otolaryngol
影响因子:
--
作者:
[Koda H, Kimura Y, Ishige T, Eishi Y, Takahashi K, Iine Y, Kitamura K]
通讯作者:
Kitamura K
Mechanotransduction in Inner Ear Hair Cells Requires Transmembrane Channel-Like Genes 1 or 2.
内耳毛细胞中的机械转导需要跨膜通道样基因 1 或 2。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kawashima Y, Geleoc G SG, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu D-K, Della Santina CC, Kitamura K, Holt JR, Griffith AJ]
通讯作者:
Griffith AJ
共 46 条
Extensive and rapid comprehensive screening for mitochondrial DNA point mutations in patients with hereditary hearing loss and quantitative analysis of mtDNA mutation in the cells of the inner ear
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批准号:21390459
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2009
-
负责人:KITAMURA Ken
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依托单位:
CDH23 mutation in deaf patients and experimental animals
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批准号:17390457
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.77万
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财政年份:2005
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负责人:KITAMURA Ken
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依托单位:
Analysis of deafness using homeobox and molecular motor gene, and knockout mouse
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批准号:14370539
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.56万
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财政年份:2002
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负责人:KITAMURA Ken
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依托单位:
Study of deafness mechanism by genetic analysis of gene knockout mouse and homeobox a well as molecular motor gene
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批准号:11470358
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.75万
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财政年份:1999
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负责人:KITAMURA Ken
-
依托单位:
Analysis of Human Sensorineural Hearing Loss by Genetic Study of Mouse with Inner Ear Anomaly
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批准号:08457455
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.56万
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财政年份:1996
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负责人:KITAMURA Ken
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依托单位:
Cytokeratin expression and CSF in cholesteatoma
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批准号:05671439
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.47万
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财政年份:1993
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负责人:KITAMURA Ken
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依托单位:
Physiological and histological study of mouse inner ear with hearing loss and dysequilibrium caused by single gene deletion.
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批准号:01480405
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.05万
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财政年份:1989
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负责人:KITAMURA Ken
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依托单位:
海外基金