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Effect of gain-of-function mutation in ASIC on vestibular and auditory function

Effect of gain-of-function mutation in ASIC on vestibular and auditory function
ASIC 功能获得性突变对前庭和听觉功能的影响
批准号:
22659307
负责人:
SHIMADA Shoichi
金额:
$2.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Members of acid sensing ion channel(ASIC) gene family are widely expressed in the central and peripheral nervous system and sensory organs including inner ear. A substitution of glycine 430 of ASIC2a by phenylalanine produced gain-of-function channel. Transfection of the mutant channel induced cell death. Transgenic rats expressing G430F-ASIC2a resulted in balance and gait disturbances.
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DOI: 10.1016/j.brainres.2010.01.016
发表时间: 2010-03-10
期刊: BRAIN RESEARCH
影响因子: 2.9
作者: [Hondoh, Aki, Ishida, Yusuke, Shimada, Shoichi]
通讯作者: Shimada, Shoichi
DOI: 10.1016/j.exer.2009.09.020
发表时间: 2010
期刊: Experimental eye research
影响因子: 3.4
作者: [Takahiro Yamada;T. Ueda;S. Ugawa;Y. Ishida;M. Imayasu;S. Koyama;S. Shimada]
通讯作者: Takahiro Yamada;T. Ueda;S. Ugawa;Y. Ishida;M. Imayasu;S. Koyama;S. Shimada
DOI: 10.1016/j.urology.2010.03.029
发表时间: 2010-08-01
期刊: UROLOGY
影响因子: 2.1
作者: [Yamada, Takahiro, Ueda, Takashi, Shimada, Shoichi]
通讯作者: Shimada, Shoichi
DOI: --
发表时间: 2011
期刊: 分子消化器病(総説)
影响因子: --
作者: [島田昌一, 石田雄介, 中村雪子, 山田貴博, 植田高史, 鵜川眞也]
通讯作者: 鵜川眞也
6
    Effect of anticancer drugs on 5-HT3 receptor subunits
    • 批准号:
      24659748
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2012
    • 负责人:
      SHIMADA Shoichi
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      19560129
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    • 资助金额:
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      2007
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    • 批准号:
      14370549
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
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    • 资助金额:
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    • 财政年份:
      2000
    • 负责人:
      SHIMADA Shoichi
    • 依托单位:
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