Effect of gain-of-function mutation in ASIC on vestibular and auditory function
Effect of gain-of-function mutation in ASIC on vestibular and auditory function
批准号:
22659307
负责人:
SHIMADA Shoichi
金额:
$2.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Members of acid sensing ion channel(ASIC) gene family are widely expressed in the central and peripheral nervous system and sensory organs including inner ear. A substitution of glycine 430 of ASIC2a by phenylalanine produced gain-of-function channel. Transfection of the mutant channel induced cell death. Transgenic rats expressing G430F-ASIC2a resulted in balance and gait disturbances.
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DOI:
10.1016/j.brainres.2010.01.016
发表时间:
2010-03-10
期刊:
BRAIN RESEARCH
影响因子:
2.9
作者:
[Hondoh, Aki, Ishida, Yusuke, Shimada, Shoichi]
通讯作者:
Shimada, Shoichi
DOI:
10.1016/j.exer.2009.09.020
发表时间:
2010
期刊:
Experimental eye research
影响因子:
3.4
作者:
[Takahiro Yamada;T. Ueda;S. Ugawa;Y. Ishida;M. Imayasu;S. Koyama;S. Shimada]
通讯作者:
Takahiro Yamada;T. Ueda;S. Ugawa;Y. Ishida;M. Imayasu;S. Koyama;S. Shimada
DOI:
10.1016/j.urology.2010.03.029
发表时间:
2010-08-01
期刊:
UROLOGY
影响因子:
2.1
作者:
[Yamada, Takahiro, Ueda, Takashi, Shimada, Shoichi]
通讯作者:
Shimada, Shoichi
ASICsについて何がわかっているか
我们对 ASIC 的了解
DOI:
--
发表时间:
2011
期刊:
分子消化器病(総説)
影响因子:
--
作者:
[島田昌一, 石田雄介, 中村雪子, 山田貴博, 植田高史, 鵜川眞也]
通讯作者:
鵜川眞也
ディジェネリン(線虫神経変性原因遺伝子)の哺乳類ホモログが引き起こす病態の解明
阐明由哺乳动物退化蛋白同源物(一种导致秀丽隐杆线虫神经变性的基因)引起的病理状况
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[鵜川眞也, 佐久間英輔, 植田高史, 木山博資, 島田昌一]
通讯作者:
島田昌一
共 6 条
Effect of anticancer drugs on 5-HT3 receptor subunits
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Effect of Cutting Speed on Cutting Phenomena and Its Limitation in High Sped Machining
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Study on Termo-Chemical Wear Mechanism of Diamond and Its Application to High Efficiency Polishing
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Thermo-Chemical Wear Mechanism of Diamond as a Tool Material
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Minimum Thickness of Cut in Micromachining
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Microstructure of Cutting Edge Affecting Minimum Thickness of Cut in Micromachining
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The Accuracy of Machine Tool Motion at Nanometer Level and Its Transfer Fidelity to Machined Surface
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依托单位:
海外基金