Development of study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes
Development of study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes
批准号:
22659363
负责人:
MORI Shiro
金额:
$2.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
The aim of the present study is to develop a study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes. In the present study, a new recombinant congenic strain of mice, which is a model for the dysplasia of bone and cartilage, was successfully established, and the onset of the disease in the mice was significantly associated with the genetic locus of FGFR2. By using the animal model and gene delivery system to the tissue around bone using nanobubbles and ultrasound, it became to be possible to perform an experimental molecular therapy using the Ig-Fc fusion protein of FGFR2 against the study model for the FGFR-related dysplasia of bone and cartilage.
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共 35 条
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项目类别:Grant-in-Aid for Scientific Research (C)
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The basic study about the cultural hierarchy of the Calligrapher in the publication in the first half of the early modern times
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依托单位:
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依托单位:
Development of imaging diagnosis system for oral cancer utilizing lesion-integrated nanobubbles and high frequency ultrasound
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批准号:22390378
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.48万
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财政年份:2010
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依托单位:
Chronological change in preschool children's motor ability and practical intervention for development promotion
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批准号:20300204
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资助金额:$12.56万
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依托单位:
An imaging and drug delivary system for treatment of oral cancer by using ultrasound and nano-bubbles
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批准号:19390507
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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依托单位:
A publication study in the first half before Genroku in the early modern times based on the bibliography explanatory notes study of the OURAIMONO printed book
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批准号:19520160
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
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A Study on the the Publication Situation of Edo Era based on OURAIMONO
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批准号:15520114
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项目类别:Grant-in-Aid for Scientific Research (C)
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Genetic and histopathological characterization of a novel arthritis model resembling rheumatoid arthritis with temporomandibular joint lesion
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批准号:15390607
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The influence of habitual physical activity patterns of preschool children on perceived motor competence and motor ability
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批准号:13680016
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资助金额:$2.24万
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财政年份:2001
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依托单位:
Genetic analysis of the susceptibility loci associated with carcinogenesis, invasion and metastasis of oral squamous cell carcinoma and establishment of an evaluation system for the carcinoma based on the genetic information
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批准号:12470434
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Establishment of animal model for Sjogren's syndrome and genetic analysis of the susceptibility loci
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An evaluation system of distant metastasis of oral squamous cell carcinoma according to the biological alterations in the course of cancer treatment
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Detection of micrometastases of oral squamous cell carcinoma in regional lymph nodes by using RT-PCR for amplification of cytokeratin 19 mRNA.
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Regulation of bone morphogeretic protein activity by additional cytokines
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批准号:06671989
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海外基金