Development of imaging diagnosis system for oral cancer utilizing lesion-integrated nanobubbles and high frequency ultrasound

点击翻译按钮获取中文摘要

The purpose of the present study is to develop a real-time imaging system using high frequency ultrasound and nanobubbles for the diagnosis of oral cancer. In order to evaluate the diagnostic accuracy of the high-frequency ultrasonic imaging analysis for oral cancer, we established a recombinant inbred strain of mouse showing a similar size of lymph node swelling as that of human. As a result, in the metastatic lymph nodes,it became clear that nanobubbles leake and integrate into the perivascular region of the lesion by enhanced permeability and retention (EPR) effect. This finding suggests that the image analysis using high-frequency ultrasound and nanobubbles isextremely useful in diagnosis of the metastatic lesions in the lymph node.