Enhanced radiation therapy using microRNA via regulation of ICAM2 signalling

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We previously reported that intercellular adhesion molecule 2 (ICAM2) gene is closely associated with radioresistant mechanism in oral squamous cell carcinoma (OSCC). And we identifind miR-125b potentially regulating ICAM2 gene expression. In this study, we evaluated the potential of targeting miRNA-125b for overcoming radio-resistance of OSCC with controled ICAM2-associated signaling. Significantly downregulated expression of miR-125b was revealed in OSCC-derived cell lines and OSCC samples when compared with human normal keratinocytes. Furthermore, miR-125b-transfected cells showed an enhanced radiosensitivity to X-ray irradiation, and diminished ICAM2 mRNA expression.The data suggest that upregulated expression of miR-125b can induce an enhanced radiosensitivity via regulation of ICAM2 signalling.