Molecular mechanisms of sarcopenia and nutritional/exercise intervention

本研究旨在探讨抗阻运动与必需氨基酸摄入相结合对肌肉合成代谢反应的影响。急性耐力运动增加了青年和老年受试者mTOR信号通路的活性。使用相同运动方案的运动训练可显著增加肌肉质量和力量。此外，结合必需氨基酸的急性抗阻运动增加了mTOR信号通路的活性。

The purpose of the study was to examine the effect of resistance exercise in combinationwith essential amino acids intake on the muscle anabolic response. Acute bout ofresistance exercise increased the activity of mTOR signaling pathway in both young andolder subjects. Exercise training using the same exercise protocol induced significantincreases in muscle mass and strength. Furthermore, an acute bout of resistance exercisein combination with essential amino acids additively increased the activity of mTORsignaling pathway.