Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2
Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2
批准号:
22700390
负责人:
UEMURA Takeshi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
The N-terminal domain of glutamate receptor GluRδ2 interacts with neurexins through secreted Cbln1. Cbln1 is a ligand for both GluRδ2 and neurexins. Trans-synaptic interaction of postsynaptic GluRδ2 and presynaptic neurexins through Cbln1 mediates parallel fiber-Purkinje cell synapse formation in the cerebellum.
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Trans-synaptic interaction of Glutamate receptorδ1 and neurexins through Cbln subtypes induces preferentially inhibitory presynaptic differentiation of cortical neurons
谷氨酸受体δ1和神经毒素通过Cbln亚型的跨突触相互作用优先诱导皮质神经元的抑制性突触前分化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[安村美里, 吉田知之, 李聖眞, 植村健, 朱宰烈, 三品昌美]
通讯作者:
三品昌美
Induction of Cbln subtypes and neurexin variants for presynaptic differentiation in cortical neurons
诱导皮层神经元突触前分化的 Cbln 亚型和神经蛋白变体
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[JY.Joo, SJ.Lee, T.Uemura, T.Yoshida, M.Yasumura, M.Watanabe, M.Mishina]
通讯作者:
M.Mishina
DOI:
10.1523/jneurosci.4637-11.2012
发表时间:
2012-02-22
期刊:
JOURNAL OF NEUROSCIENCE
影响因子:
5.3
作者:
[Yoshida, Tomoyuki, Shiroshima, Tomoko, Mishina, Masayoshi]
通讯作者:
Mishina, Masayoshi
DOI:
10.1016/j.cell.2010.04.035
发表时间:
2010-06-11
期刊:
CELL
影响因子:
64.5
作者:
[Uemura, Takeshi, Lee, Sung-Jin, Mishina, Masayoshi]
通讯作者:
Mishina, Masayoshi
Interaction among GluRδ2, Cbln1 and NRXN1βin the trans-synaptic triad essential for cerebellar synapse formation
小脑突触形成所必需的跨突触三联体中 GluRδ2、Cbln1 和 NRXN1β 之间的相互作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[李聖眞, 植村健, 吉田知之, 三品昌美]
通讯作者:
三品昌美
共 40 条
Advanced technology development for analyzing molecular dynamics and structure in synapse formation
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批准号:26640039
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2014
-
负责人:UEMURA Takeshi
-
依托单位:
Study on molecular mechanism of cerebellar circuit formation
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批准号:25290021
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.82万
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财政年份:2013
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负责人:UEMURA Takeshi
-
依托单位:
Development of the novel biomarker for tissue damage using polyamines and their metabolites
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批准号:24890195
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项目类别:Grant-in-Aid for Research Activity Start-up
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资助金额:$1.91万
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财政年份:2012
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负责人:UEMURA Takeshi
-
依托单位:
New Development of surgical techniques at tissue transfer - application of synthetic double-stranded oligodeoxynucleotide -
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批准号:23792041
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:UEMURA Takeshi
-
依托单位:
Study on the functional roles of the N-terminal domain of GluRδ2
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批准号:20700330
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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负责人:UEMURA Takeshi
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依托单位:
海外基金