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Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2

Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2
谷氨酸受体(GluR)δ2突触形成的分子机制研究
批准号:
22700390
负责人:
UEMURA Takeshi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
The N-terminal domain of glutamate receptor GluRδ2 interacts with neurexins through secreted Cbln1. Cbln1 is a ligand for both GluRδ2 and neurexins. Trans-synaptic interaction of postsynaptic GluRδ2 and presynaptic neurexins through Cbln1 mediates parallel fiber-Purkinje cell synapse formation in the cerebellum.
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会议论文
Trans-synaptic interaction of Glutamate receptorδ1 and neurexins through Cbln subtypes induces preferentially inhibitory presynaptic differentiation of cortical neurons
谷氨酸受体δ1和神经毒素通过Cbln亚型的跨突触相互作用优先诱导皮质神经元的抑制性突触前分化
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [安村美里, 吉田知之, 李聖眞, 植村健, 朱宰烈, 三品昌美]
通讯作者: 三品昌美
Induction of Cbln subtypes and neurexin variants for presynaptic differentiation in cortical neurons
诱导皮层神经元突触前分化的 Cbln 亚型和神经蛋白变体
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [JY.Joo, SJ.Lee, T.Uemura, T.Yoshida, M.Yasumura, M.Watanabe, M.Mishina]
通讯作者: M.Mishina
DOI: 10.1523/jneurosci.4637-11.2012
发表时间: 2012-02-22
期刊: JOURNAL OF NEUROSCIENCE
影响因子: 5.3
作者: [Yoshida, Tomoyuki, Shiroshima, Tomoko, Mishina, Masayoshi]
通讯作者: Mishina, Masayoshi
DOI: 10.1016/j.cell.2010.04.035
发表时间: 2010-06-11
期刊: CELL
影响因子: 64.5
作者: [Uemura, Takeshi, Lee, Sung-Jin, Mishina, Masayoshi]
通讯作者: Mishina, Masayoshi
40
    Advanced technology development for analyzing molecular dynamics and structure in synapse formation
    • 批准号:
      26640039
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2014
    • 负责人:
      UEMURA Takeshi
    • 依托单位:
    Study on molecular mechanism of cerebellar circuit formation
    • 批准号:
      25290021
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.82万
    • 财政年份:
      2013
    • 负责人:
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    Development of the novel biomarker for tissue damage using polyamines and their metabolites
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      24890195
    • 项目类别:
      Grant-in-Aid for Research Activity Start-up
    • 资助金额:
      $1.91万
    • 财政年份:
      2012
    • 负责人:
      UEMURA Takeshi
    • 依托单位:
    New Development of surgical techniques at tissue transfer - application of synthetic double-stranded oligodeoxynucleotide -
    • 批准号:
      23792041
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2011
    • 负责人:
      UEMURA Takeshi
    • 依托单位:
    海外基金