Mechanism of dipeptide synthesis mediated by prolyl aminopeptidase

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Protease hydrolyze protein and release corresponding peptides. It is known that protease also exert synthetic reaction of peptide. Especially, Ser/Cys substituted protease shows increased synthetic activity. In this study, we revealed that Ser/Cys modified prolyl aminopeptidase also exert increased synthetic activity of proline containing dipeptides. Furthermore we established the enzymatic synthetic method of prolyl hydroxylproline which has attracted attention to prevent locomotive syndrome.