Effects of insulin resistance-related factors on the stem cell functions in vivo.
Effects of insulin resistance-related factors on the stem cell functions in vivo.
批准号:
23390056
负责人:
IMAMURA Takeshi
金额:
$11.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
In this study, we planned to investigate whether the stem cell functions are damaged under the diabetic and/or insulin resistant conditions. Using the iPS cells established with the skin fibroblast of cynomolgus monkey, we identified the inhibitory effects of insulin resistant factor, IL-1beta on the ability of differentiation from iPS cells in vitro and in vivo. Thus, it is suggested that the stem cell functions are modified by the insulin resistant factors.
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Effects of insulin resistance on adipogenic differentiation of the stem cells transplanted in cynomolgus monkeys
胰岛素抵抗对食蟹猴干细胞移植成脂分化的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[山本 渉, 橋本 哲郎, 松浦 潤治, 荻野恭浩, 町田 泰一, 小林 恒文, 山中 義弘, 石綿 紀久, 山下 徹, 谷本 耕司郎, 三好俊一郎, 中谷 晴昭, 小川 聡, 今村武史]
通讯作者:
今村武史
Chronic Administration of Nicotine-Free Cigarette Smoke Extract Impaired Endothelium-Dependent Vascular Relaxation in Rats via Increased Vascular Oxidative Stress
长期服用不含尼古丁的香烟烟雾提取物会增加血管氧化应激,从而损害大鼠内皮依赖性血管舒张功能
DOI:
10.1254/jphs.11187fp
发表时间:
2012
期刊:
Journal of Pharmacological Sciences
影响因子:
3.5
作者:
[Shimosato, Geddawy, Tawa, Imamura, Okamura]
通讯作者:
Okamura
GSK3beta differentially modifies early and late stages of adipogenesis from the pluripotent stem cells to mature adipocytes
GSK3beta 差异性地改变从多能干细胞到成熟脂肪细胞的脂肪生成的早期和晚期阶段
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[今村武史, 岩崎広高, 田和正志, 下里 貴, 岡村富夫]
通讯作者:
岡村富夫
Inhibition of Glycogen Synthase Kinase-3 beta enhances adipogenesis via the stimulation of glucose transport in mesenchymal stem cells
糖原合成酶激酶 3 beta 的抑制通过刺激间充质干细胞中的葡萄糖转运来增强脂肪生成
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Matsubara J, Sugiyama S, Sugamura K,Nakamura T, Fujiwara Y, Akiyama E,Kurokawa H, Nozaki T, Ohba K, Konishi M,Maeda H, Izumiya Y, Kaikita K, Sumida H,Jinnouchi H, Matsui K, Kim-Mitsuyama S,Takeya M, Ogawa H, Onaka T, 今村武史]
通讯作者:
今村武史
Inhibition of GSK3beta enhances adipogenesis via the stimulation of glucose transport.
GSK3beta 的抑制通过刺激葡萄糖转运来增强脂肪生成。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Onaka T, Takayanagi Y, Takeshi Imamura]
通讯作者:
Takeshi Imamura
共 14 条
The mechanisms of Galectin3-induced stem cell dysfunction and the effects of anti-galectin3 therapy
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批准号:19H03378
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2019
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负责人:IMAMURA Takeshi
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依托单位:
Microscale processes in the Venus atmosphere revealed by radio occultation
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批准号:24540482
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2012
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Development of advanced fluorescent imaging systems for the study of bone remodeling
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批准号:23390368
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2011
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负责人:IMAMURA Takeshi
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依托单位:
Development of advanced in vivo EMT imaging system and its application for the study of cancer metastasis
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批准号:23650600
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:IMAMURA Takeshi
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依托单位:
Sturm und Drang in the history of European culture
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批准号:22520328
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2010
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负责人:IMAMURA Takeshi
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依托单位:
Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging
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批准号:20390407
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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财政年份:2008
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负责人:IMAMURA Takeshi
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依托单位:
Improvements of radio occultations of lunar and planetary atmospheres
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批准号:20740289
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.16万
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财政年份:2008
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负责人:IMAMURA Takeshi
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依托单位:
Analysis of TGF-β/BMP signaling during bone metastasis and development of cancer therapy
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批准号:17390422
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.72万
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财政年份:2005
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负责人:IMAMURA Takeshi
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依托单位:
Screening of novel signal transducers for BMP using DNA affinity purification
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批准号:15591611
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:IMAMURA Takeshi
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依托单位:
Screening and characterization of BMP-specific R-Smads binding proteins
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批准号:13671554
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:IMAMURA Takeshi
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依托单位: