Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging
Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging
批准号:
20390407
负责人:
IMAMURA Takeshi
金额:
$12.31万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
为了明确TGF-β/BMP信号在乳腺癌骨转移部位血管生成中的作用,我们开发了先进的体内光学成像系统,可以同时观察肿瘤血管生成和TGF-β/BMP。此外,我们还在体内研究了血管生成抑制剂和TGF-β/BMP信号阻滞剂在乳腺癌骨转移中的作用。
英文摘要
In order to clarify the roles of TGF-β/BMP signaling during angiogenesis in bone metastasis sites of breast cancer, we developed advanced in vivo optical imaging systems by which we can visualize tumor angiogenesis and TGF-β/BMP at the same time. In addition, we studied the effects of angiogenesis inhibitors and TGF-β/BMP signaling blockers during bone metastasis of breast cancer in vivo.
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DOI:
10.1091/mbc.e08-03-0329
发表时间:
2008-12-01
期刊:
MOLECULAR BIOLOGY OF THE CELL
影响因子:
3.3
作者:
[Tominaga, Hiroyuki, Maeda, Shingo, Imamura, Takeshi]
通讯作者:
Imamura, Takeshi
Role of Ras signaling in the induction of snail by TGF-b
Ras 信号在 TGF-b 诱导蜗牛中的作用
DOI:
--
发表时间:
2009
期刊:
J Biol Chem 284
影响因子:
--
作者:
[Horiguchi K, Shirakihara T, Nakano A, Imamura T, Miyazono K, Saitoh M]
通讯作者:
Saitoh M
DOI:
10.1111/j.1349-7006.2009.01305.x
发表时间:
2009-11-01
期刊:
CANCER SCIENCE
影响因子:
5.7
作者:
[Hanyu, Aki, Kojima, Kiyotsugu, Imamura, Takeshi]
通讯作者:
Imamura, Takeshi
DOI:
10.1038/onc.2008.232
发表时间:
2008-10-01
期刊:
ONCOGENE
影响因子:
8
作者:
[Katsuno, Y., Hanyu, A., Imamura, T.]
通讯作者:
Imamura, T.
革新的インビボ光イメージングの骨代謝への応用
创新体内光学成像在骨代谢中的应用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tanaka S, Sakai A, Nakamura T, et al., 和田卓郎, 今村健志]
通讯作者:
今村健志
共 26 条
The mechanisms of Galectin3-induced stem cell dysfunction and the effects of anti-galectin3 therapy
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批准号:19H03378
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2019
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负责人:IMAMURA Takeshi
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Microscale processes in the Venus atmosphere revealed by radio occultation
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批准号:24540482
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财政年份:2012
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Effects of insulin resistance-related factors on the stem cell functions in vivo.
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批准号:23390056
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2011
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负责人:IMAMURA Takeshi
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依托单位:
Development of advanced fluorescent imaging systems for the study of bone remodeling
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批准号:23390368
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2011
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负责人:IMAMURA Takeshi
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依托单位:
Development of advanced in vivo EMT imaging system and its application for the study of cancer metastasis
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批准号:23650600
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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Sturm und Drang in the history of European culture
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批准号:22520328
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2010
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负责人:IMAMURA Takeshi
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依托单位:
Improvements of radio occultations of lunar and planetary atmospheres
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批准号:20740289
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.16万
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财政年份:2008
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负责人:IMAMURA Takeshi
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依托单位:
Analysis of TGF-β/BMP signaling during bone metastasis and development of cancer therapy
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批准号:17390422
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.72万
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财政年份:2005
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负责人:IMAMURA Takeshi
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依托单位:
Screening of novel signal transducers for BMP using DNA affinity purification
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批准号:15591611
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:IMAMURA Takeshi
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依托单位:
Screening and characterization of BMP-specific R-Smads binding proteins
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批准号:13671554
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:IMAMURA Takeshi
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依托单位:
海外基金