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Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging

Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging
利用体内光学成像研究骨转移部位血管生成过程中的 TGFβ 信号传导
批准号:
20390407
负责人:
IMAMURA Takeshi
金额:
$12.31万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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相关文献

中文摘要
翻译
为了明确TGF-β/BMP信号在乳腺癌骨转移部位血管生成中的作用,我们开发了先进的体内光学成像系统,可以同时观察肿瘤血管生成和TGF-β/BMP。此外,我们还在体内研究了血管生成抑制剂和TGF-β/BMP信号阻滞剂在乳腺癌骨转移中的作用。
英文摘要
In order to clarify the roles of TGF-β/BMP signaling during angiogenesis in bone metastasis sites of breast cancer, we developed advanced in vivo optical imaging systems by which we can visualize tumor angiogenesis and TGF-β/BMP at the same time. In addition, we studied the effects of angiogenesis inhibitors and TGF-β/BMP signaling blockers during bone metastasis of breast cancer in vivo.
期刊论文(0)
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科研奖励(0)
会议论文
DOI: 10.1091/mbc.e08-03-0329
发表时间: 2008-12-01
期刊: MOLECULAR BIOLOGY OF THE CELL
影响因子: 3.3
作者: [Tominaga, Hiroyuki, Maeda, Shingo, Imamura, Takeshi]
通讯作者: Imamura, Takeshi
Role of Ras signaling in the induction of snail by TGF-b
Ras 信号在 TGF-b 诱导蜗牛中的作用
DOI: --
发表时间: 2009
期刊: J Biol Chem 284
影响因子: --
作者: [Horiguchi K, Shirakihara T, Nakano A, Imamura T, Miyazono K, Saitoh M]
通讯作者: Saitoh M
DOI: 10.1111/j.1349-7006.2009.01305.x
发表时间: 2009-11-01
期刊: CANCER SCIENCE
影响因子: 5.7
作者: [Hanyu, Aki, Kojima, Kiyotsugu, Imamura, Takeshi]
通讯作者: Imamura, Takeshi
DOI: 10.1038/onc.2008.232
发表时间: 2008-10-01
期刊: ONCOGENE
影响因子: 8
作者: [Katsuno, Y., Hanyu, A., Imamura, T.]
通讯作者: Imamura, T.
26
    The mechanisms of Galectin3-induced stem cell dysfunction and the effects of anti-galectin3 therapy
    • 批准号:
      19H03378
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2019
    • 负责人:
      IMAMURA Takeshi
    • 依托单位:
    Microscale processes in the Venus atmosphere revealed by radio occultation
    • 批准号:
      24540482
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.66万
    • 财政年份:
      2012
    • 负责人:
      IMAMURA Takeshi
    • 依托单位:
    Effects of insulin resistance-related factors on the stem cell functions in vivo.
    • 批准号:
      23390056
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2011
    • 负责人:
      IMAMURA Takeshi
    • 依托单位:
    Development of advanced fluorescent imaging systems for the study of bone remodeling
    • 批准号:
      23390368
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.06万
    • 财政年份:
      2011
    • 负责人:
      IMAMURA Takeshi
    • 依托单位:
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