Research on the molecular mechanism of metabolic syndrome and cardiovascular diseases and novel therapeutic strategy for these diseases

研究ASK1和肾神经在代谢综合征和脑血管、心血管疾病中的分子机制，为这些疾病的治疗提供有前景的策略。ASK1参与慢性脑缺血或高脂饮食引起的认知障碍。肾去神经抑制代谢综合征引起的血压昼夜节律异常和心血管疾病，预防脑血管疾病的发生，提示肾神经是脑血管疾病的治疗靶点。此外，ask1结合蛋白ASK2被发现参与盐敏感性高血压和心血管疾病。因此，ASK1和肾神经似乎是一个有希望的治疗脑血管和心血管疾病的靶点。

The role of ASK1 and renal nerve was investigated to examine the molecular mechanism of metabolic syndrome and cerebrovascular and cardiovascular diseases and to develop promising therapeutic strategies for these diseases. ASK1 was involved in cognitive impairment induced by chronic cerebral ischemia or high-fat diet. Renal denervation suppressed the abnormality of blood pressure circadian rhythm and cardiovascular diseases induced by metabolic syndrome and also prevented the onset of cerebrovascular disease, thereby suggesting renal nerve as a promising therapeutic target for cerebrovascular and cardiovascular diseases. Furthermore, ASK2, the ASK1-binding protein, was found to participate in salt-sensitive hypertension and cardiovascular diseases. Thus, ASK1 and renal nerve seem to be a promising therapeutic target for cerebrovascular and cardiovascular diseases.