课题基金 / 基金详情

The effects of aqueous bioactive molecules on aqueous outflow dynamics and filtration-surgery results

The effects of aqueous bioactive molecules on aqueous outflow dynamics and filtration-surgery results
水性生物活性分子对房水流出动力学和滤过手术结果的影响
批准号:
23390403
负责人:
TANIHARA Hidenobu
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

项目摘要

项目成果

TANIHARA Hidenobu的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The concentrations of IL-8, MCP-1, EGF and PDGF-AA were elevated in the glaucomatous aqueous humor. The history of cataract surgery affected the aqueous MCP-1 concentraiotn, which was the highest among the cytokines. MCP-1 treatment changed the intracellular localization of ZO-1, increased permeability of the monolayer of Schlemm's canal endothelial cells, and increased aqueous outflow. MCP-1 expressed in the rabbit iris and ciliary body, and phacoemulsification surgery increased its expression in the cornea, iris and ciliary body transiently, while the surgery induced time-dependent increase of its expression only in the lens capsule. We confirmed the MCP-1 expression in the lens epithelial cells after surgery. These results indicate that aqueous MCP-1 may be involved in the glaucoma pathology.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
シンポジウム「緑内障と白内障手術」緑内障眼に対する白内障手術の功罪
“青光眼与白内障手术”研讨会青光眼白内障手术的优点和缺点
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [辻井雅也, 飯田竜, 里中東彦, 植村剛, 吉川智朗, 平田仁, 須藤啓広, 渋沢崇行,並木淳,鈴木さゆり,林田敬,関根和彦,佐々木淳一,堀進悟, 井上俊洋]
通讯作者: 井上俊洋
DOI: 10.1074/jbc.m112.370130
发表时间: 2012-07-20
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Hayashi, Hideki, Eguchi, Yuko, Tanihara, Hidenobu]
通讯作者: Tanihara, Hidenobu
DOI: 10.1167/iovs.12-10231
发表时间: 2012-12-01
期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子: 4.4
作者: [Kawai, Motofumi, Inoue, Toshihiro, Tanihara, Hidenobu]
通讯作者: Tanihara, Hidenobu
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Nakashima K, Inoue T, Fukushima A, Hirakawa S, Kawaji T, Tanihara H]
通讯作者: Tanihara H
52
    Study on development of new therapeutic methods based on plasticity of trabecular meshwork cells
    • 批准号:
      17K19729
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.08万
    • 财政年份:
      2017
    • 负责人:
      TANIHARA Hidenobu
    • 依托单位:
    Investigation of glaucoma pathology focusing on epigenome and fibrocyte in aqueous humor dynamics and wound healing
    • 批准号:
      17H04351
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.9万
    • 财政年份:
      2017
    • 负责人:
      TANIHARA Hidenobu
    • 依托单位:
    4-dimention live imaging of inflamatory cells in conjunctiva after glaucoma surgery
    • 批准号:
      25670735
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      TANIHARA Hidenobu
    • 依托单位:
    Establishment of therapeutic assessment in glaucoma neuroprotection using live-imaging of axonal transport in optic nerve
    • 批准号:
      23659814
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      TANIHARA Hidenobu
    • 依托单位:
    海外基金