The effects of aqueous bioactive molecules on aqueous outflow dynamics and filtration-surgery results
The effects of aqueous bioactive molecules on aqueous outflow dynamics and filtration-surgery results
批准号:
23390403
负责人:
TANIHARA Hidenobu
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The concentrations of IL-8, MCP-1, EGF and PDGF-AA were elevated in the glaucomatous aqueous humor. The history of cataract surgery affected the aqueous MCP-1 concentraiotn, which was the highest among the cytokines. MCP-1 treatment changed the intracellular localization of ZO-1, increased permeability of the monolayer of Schlemm's canal endothelial cells, and increased aqueous outflow. MCP-1 expressed in the rabbit iris and ciliary body, and phacoemulsification surgery increased its expression in the cornea, iris and ciliary body transiently, while the surgery induced time-dependent increase of its expression only in the lens capsule. We confirmed the MCP-1 expression in the lens epithelial cells after surgery. These results indicate that aqueous MCP-1 may be involved in the glaucoma pathology.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
シンポジウム「緑内障と白内障手術」緑内障眼に対する白内障手術の功罪
“青光眼与白内障手术”研讨会青光眼白内障手术的优点和缺点
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[辻井雅也, 飯田竜, 里中東彦, 植村剛, 吉川智朗, 平田仁, 須藤啓広, 渋沢崇行,並木淳,鈴木さゆり,林田敬,関根和彦,佐々木淳一,堀進悟, 井上俊洋]
通讯作者:
井上俊洋
DOI:
10.1074/jbc.m112.370130
发表时间:
2012-07-20
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Hayashi, Hideki, Eguchi, Yuko, Tanihara, Hidenobu]
通讯作者:
Tanihara, Hidenobu
Elevated Levels of Monocyte Chemoattractant Protein-1 in the Aqueous Humor after Phacoemulsification
DOI:
10.1167/iovs.12-10231
发表时间:
2012-12-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Kawai, Motofumi, Inoue, Toshihiro, Tanihara, Hidenobu]
通讯作者:
Tanihara, Hidenobu
Evaluation of filtering blebs with transconjunctival oozing by anterior segment optical coherence tomography
眼前段光学相干断层扫描评估经结膜渗出的滤过泡
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Nakashima K, Inoue T, Fukushima A, Hirakawa S, Kawaji T, Tanihara H]
通讯作者:
Tanihara H
Filtration Bleb-associated Tear Film Sign Demonstrated by Three Dimensional Anterior Segment Optical Coherence Tomography (3D AS-OCT).
三维眼前段光学相干断层扫描 (3D AS-OCT) 显示滤过泡相关泪膜征象。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsuboi N, Inoue T, Fujimoto T, Inoue-Mochita M, Kasaoka N, Kawai M, Shobayashi K, Yoshida A, Tanihara H, Kojima S, Kawai M, Tanihara H, Fujimoto T, Tsuboi N, Takihara Y, Kojima S]
通讯作者:
Kojima S
共 52 条
Study on development of new therapeutic methods based on plasticity of trabecular meshwork cells
-
批准号:17K19729
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$4.08万
-
财政年份:2017
-
负责人:TANIHARA Hidenobu
-
依托单位:
Investigation of glaucoma pathology focusing on epigenome and fibrocyte in aqueous humor dynamics and wound healing
-
批准号:17H04351
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.9万
-
财政年份:2017
-
负责人:TANIHARA Hidenobu
-
依托单位:
4-dimention live imaging of inflamatory cells in conjunctiva after glaucoma surgery
-
批准号:25670735
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:TANIHARA Hidenobu
-
依托单位:
Establishment of therapeutic assessment in glaucoma neuroprotection using live-imaging of axonal transport in optic nerve
-
批准号:23659814
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:TANIHARA Hidenobu
-
依托单位:
New therapeutic approach for glaucoma via drug-mediated bleb regulation
-
批准号:20390449
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.31万
-
财政年份:2008
-
负责人:TANIHARA Hidenobu
-
依托单位:
The investigation for molecular mechanisms of aqueous humor outflow and the creation of new treatments for intraocular pressure elevation in glaucomatous eyes
-
批准号:18390470
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.59万
-
财政年份:2006
-
负责人:TANIHARA Hidenobu
-
依托单位:
The development and clinical application of molecular-based new medical treatments for glaucoma
-
批准号:16390500
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.22万
-
财政年份:2004
-
负责人:TANIHARA Hidenobu
-
依托单位:
A research about the new therapy for glaucomatous optic nerve damage based on the endogenous neuroprotective system
-
批准号:14370561
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2002
-
负责人:TANIHARA Hidenobu
-
依托单位:
Development of gene theropy for glaucoma by neaws of modulation of proteoglycan praduction in aqueous outflow rocite
-
批准号:08457464
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1996
-
负责人:TANIHARA Hidenobu
-
依托单位:
海外基金