The effects of aqueous bioactive molecules on aqueous outflow dynamics and filtration-surgery results

水性生物活性分子对房水流出动力学和滤过手术结果的影响

• 批准号: 23390403
• 负责人: TANIHARA Hidenobu
• 金额: $ 11.98万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390403/
• 关键词: 緑内障; サイトカイン; 房水; MCP-1; 線維柱体; シュレム管

The concentrations of IL-8, MCP-1, EGF and PDGF-AA were elevated in the glaucomatous aqueous humor. The history of cataract surgery affected the aqueous MCP-1 concentraiotn, which was the highest among the cytokines. MCP-1 treatment changed the intracellular localization of ZO-1, increased permeability of the monolayer of Schlemm's canal endothelial cells, and increased aqueous outflow. MCP-1 expressed in the rabbit iris and ciliary body, and phacoemulsification surgery increased its expression in the cornea, iris and ciliary body transiently, while the surgery induced time-dependent increase of its expression only in the lens capsule. We confirmed the MCP-1 expression in the lens epithelial cells after surgery. These results indicate that aqueous MCP-1 may be involved in the glaucoma pathology.

青光眼房水中IL-8、MCP-1、EGF和PDGF-AA的浓度升高。白内障手术史影响白内障眼房水中MCP-1的浓度，其中MCP-1浓度最高。MCP-1处理改变了ZO-1的细胞内定位，增加了施累姆氏管内皮细胞单层的通透性，并增加了水流出。MCP-1在兔眼虹膜和睫状体中均有表达，超声乳化手术后其在角膜、虹膜和睫状体中的表达短暂增加，而手术后其表达仅在透镜囊中呈时间依赖性增加。我们证实MCP-1在手术后的透镜上皮细胞中表达。这些结果表明，水MCP-1可能参与青光眼病理。

项目成果

シンポジウム「緑内障と白内障手術」緑内障眼に対する白内障手術の功罪

“青光眼与白内障手术”研讨会青光眼白内障手术的优点和缺点

• 发表时间: 2011
• 作者: 辻井雅也;飯田竜;里中東彦;植村剛;吉川智朗;平田仁;須藤啓広;渋沢崇行，並木淳，鈴木さゆり，林田敬，関根和彦，佐々木淳一，堀進悟;井上俊洋
• 通讯作者: 井上俊洋

A Potential Neuroprotective Role of Apolipoprotein E-containing Lipoproteins through Low Density Lipoprotein Receptor-related Protein 1 in Normal Tension Glaucoma

• DOI: 10.1074/jbc.m112.370130
• 发表时间: 2012-07-20
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Hayashi, Hideki;Eguchi, Yuko;Tanihara, Hidenobu
• 通讯作者: Tanihara, Hidenobu

Elevated Levels of Monocyte Chemoattractant Protein-1 in the Aqueous Humor after Phacoemulsification

• DOI: 10.1167/iovs.12-10231
• 发表时间: 2012-12-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Kawai, Motofumi;Inoue, Toshihiro;Tanihara, Hidenobu
• 通讯作者: Tanihara, Hidenobu

Evaluation of filtering blebs with transconjunctival oozing by anterior segment optical coherence tomography

眼前段光学相干断层扫描评估经结膜渗出的滤过泡

• 发表时间: 2013
• 作者: Nakashima K;Inoue T;Fukushima A;Hirakawa S;Kawaji T;Tanihara H
• 通讯作者: Tanihara H

Filtration Bleb-associated Tear Film Sign Demonstrated by Three Dimensional Anterior Segment Optical Coherence Tomography (3D AS-OCT).

三维眼前段光学相干断层扫描 (3D AS-OCT) 显示滤过泡相关泪膜征象。

• 发表时间: 2012
• 作者: Tsuboi N;Inoue T;Fujimoto T;Inoue-Mochita M;Kasaoka N;Kawai M;Shobayashi K;Yoshida A;Tanihara H;Kojima S;Kawai M;Tanihara H;Fujimoto T;Tsuboi N;Takihara Y;Kojima S
• 通讯作者: Kojima S