A research about the new therapy for glaucomatous optic nerve damage based on the endogenous neuroprotective system

基于内源性神经保护系统的青光眼视神经损伤新疗法研究

• 批准号: 14370561
• 负责人: TANIHARA Hidenobu
• 金额: $ 9.54万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370561/
• 关键词: glaucoma; neuroprotection; cytokine; statin; antithrombin III; familial amyloid polyneuropathy; endogenous survival factor; SEREX法

In this research, we investigated our hypothesis that immune reaction and stress response exerted neuroprotective effect on glaucomatous optic nerve damage. First, we reported that IL-6, multifunctional cytokine produced by several cells, provided a neuroproctive effect on retinal damage (BBRC 302:226,2003). Second, we demonstrated the neuroprotective effect of statin (Arch Ophthalmol 120:1707,2002) and antithrombin III (IOVS 44:332,2003) and the beneficial effects of anti-LOX-1 antibody on the endotoxin-induced inflammation (Pro Natl Acad Sci USA 100:1274,2003) by inhibiting leukocyte-endothelial interaction. Third, we demonstrated the neuroprotective effect of LEDGF, enodogenous and exogenous survival factor, on retinal damage (Brain Res 991:163,2003). Fourth, we elucidated the clinical and surgical outcomes of the treatment of unique type of secondary glaucoma associated with transthyretin related familial amyliod polyneuropathy (Arch Ophthalmol 121:351,2003).

本研究探讨了免疫反应和应激反应在青光眼视神经损伤中发挥神经保护作用的假说。首先，我们报道了IL-6，由几种细胞产生的多功能细胞因子，对视网膜损伤提供神经保护作用（BBRC 302：226，2003）。其次，我们证明了他汀类药物（Arch Ophthalmol 120：1707，2002）和抗凝血酶III（IOVS 44：332，2003）的神经保护作用以及抗LOX-1抗体通过抑制白细胞-内皮细胞相互作用对内毒素诱导的炎症的有益作用（ProNatl Acad Sci USA 100：1274，2003）。第三，我们证明了LEDGF（内源性和外源性存活因子）对视网膜损伤的神经保护作用（Brain Res 991：163，2003）。第四，我们阐明了与甲状腺素运载蛋白相关的家族性淀粉样多发性神经病相关的独特类型的继发性青光眼的治疗的临床和手术结果（Arch Ophthalmol 121：351，2003）。

项目成果

Inomata Y, Hirata A, Yonemura N, Koga T, Kido N, Tanihara H: "Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage"Biochem Biophys Res Commun. 302(2). 226-232 (2003)

Inomata Y、Hirata A、Yonemura N、Koga T、Kido N、Tanihara H：“白细胞介素 6 对 NMDA 诱导的大鼠视网膜损伤的神经保护作用”Biochem Biophys Res Commun。

Honjo M, et al.: "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation."Proc Natl Acad Sci USA. 100. 1274-1279 (2003)

Honjo M 等人：“凝集素样氧化 LDL 受体 1 是一种参与内毒素诱导炎症的细胞粘附分子。”Proc Natl Acad Sci USA。

Nishijima K, Kiryu J, Tsujikawa A, Honjo M, Nonaka A, Yamashiro K, Kamizuru H, Ieki Y, Tanihara H, Honda Y, Ogura Y: "Inhibitory effects of antithrombin III on interactions between blood cells and endothelial cells during retinal ischemia-reperfusion inju

Nishijima K、Kiryu J、Tsujikawa A、Honjo M、Nonaka A、Yamashiro K、Kamizuru H、Ieki Y、Tanihara H、Honda Y、Ogura Y：“抗凝血酶 III 对视网膜缺血期间血细胞和内皮细胞之间相互作用的抑制作用

Inomata Y, Hirata A, Koga T, Kimura A, Singh DP, Shinohara T, Tanihara H: "Lens epithelium-derived growth factor : neuroprotection on rat retinal damage induced by N-methyl-D-aspartate"Brain Research. 991・1-2. 163-170 (2003)

Inomata Y、Hirata A、Koga T、Kimura A、Singh DP、筱原 T、Tanihara H：“晶状体上皮源性生长因子：N-甲基-D-天冬氨酸诱导的大鼠视网膜损伤的神经保护”脑研究 991・1。 -2。163-170（2003）

Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura, T: "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation"Proc Natl Acad Sci U S A. 100・3. 1274

Honjo M、Nakamura K、Yamashiro K、Kiryu J、Tanihara H、McEvoy LM、Honda Y、Butcher EC、Masaki T、Sawamura、T：“凝集素样氧化 LDL 受体 1 是一种细胞粘附分子，参与内毒素-炎症诱发“Proc Natl Acad Sci U S A. 100・3. 1274