A research about the new therapy for glaucomatous optic nerve damage based on the endogenous neuroprotective system

在本研究中，我们探讨了免疫反应和应激反应对青光眼视神经损伤的神经保护作用。首先，我们报道了几种细胞产生的多功能细胞因子IL-6对视网膜损伤具有神经保护作用（BBRC 302:226,2003）。其次，我们证明了他汀类药物（Arch Ophthalmol 120:1707,2002）和抗凝血酶III （IOVS 44:332,2003）的神经保护作用，以及抗lox -1抗体通过抑制白细胞内皮相互作用对内毒素诱导的炎症的有益作用（Pro Natl Acad Sci USA 100:1274,2003）。第三，我们证明了内源性和外源性存活因子LEDGF对视网膜损伤的神经保护作用（Brain Res 991:163,2003）。第四，我们阐明了特殊类型继发性青光眼合并甲状腺素相关家族性淀粉样多神经病变的临床和手术治疗结果（Arch Ophthalmol 121:351,2003）。

In this research, we investigated our hypothesis that immune reaction and stress response exerted neuroprotective effect on glaucomatous optic nerve damage. First, we reported that IL-6, multifunctional cytokine produced by several cells, provided a neuroproctive effect on retinal damage (BBRC 302:226,2003). Second, we demonstrated the neuroprotective effect of statin (Arch Ophthalmol 120:1707,2002) and antithrombin III (IOVS 44:332,2003) and the beneficial effects of anti-LOX-1 antibody on the endotoxin-induced inflammation (Pro Natl Acad Sci USA 100:1274,2003) by inhibiting leukocyte-endothelial interaction. Third, we demonstrated the neuroprotective effect of LEDGF, enodogenous and exogenous survival factor, on retinal damage (Brain Res 991:163,2003). Fourth, we elucidated the clinical and surgical outcomes of the treatment of unique type of secondary glaucoma associated with transthyretin related familial amyliod polyneuropathy (Arch Ophthalmol 121:351,2003).