Effect of senescent adipose tissue on periodontal disease states

衰老脂肪组织对牙周病状态的影响

• 批准号: 23390482
• 负责人: AKIFUSA Sumio
• 金额: $ 10.98万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390482/
• 关键词: アディポカイン; apelin; 歯周疾患; マクロファージ; 老化; 肥満

we investigated whether newly identified adipokine apelin had an inhibitory effect on inflammatory response in lipopolysaccharide (LPS) -treated macrophage. Pretreatment with apelin significantly reduced the production of proinflammatory cytokines in LPS-treated macrophage-like cell line, J774.1 cell. In addition, apelin pretreatment significantly reduced the LPS-induced phosphorylation of p38 MAPK and JNK, but not ERK. To the best of our knowledge, this is the first report that the apelin peptide family has anti-inflammatory effects against bacterial LPS stimulation in macrophages.

我们研究了新发现的脂肪因子apelin是否对脂多糖(LPS)处理的巨噬细胞的炎症反应有抑制作用。Apelin可显著降低脂多糖诱导的巨噬细胞样细胞系J774.1细胞促炎细胞因子的产生。此外，Apelin可显著降低脂多糖诱导的p38MAPK和JNK的磷酸化，但对ERK的磷酸化无明显影响。据我们所知，这是首次报道apelin多肽家族对细菌内毒素刺激巨噬细胞具有抗炎作用。

项目成果

Relationship between nutrition status and dental occlusion in community-dwelling frail elderly people

• DOI: 10.1111/j.1447-0594.2012.00855.x
• 发表时间: 2013-01-01
• 期刊: GERIATRICS & GERONTOLOGY INTERNATIONAL
• 影响因子: 3.3
• 作者: Kikutani, Takeshi;Yoshida, Mitsuyoshi;Tamura, Fumio
• 通讯作者: Tamura, Fumio

Activities of daily living dependency and disease-specific mortality during 12-year follow-up in an 80-year-old population

80 岁人群 12 年随访期间的日常生活依赖活动和疾病特异性死亡率

• DOI: 10.1007/s40520-013-0029-6
• 发表时间: 2013
• 期刊: Aging Clin Exp Res
• 影响因子: 4
• 作者: Takata Y;Ansai T;Soh I;Awano S;Nakamichi I;Akifusa S;Goto K;Yoshida A;Sonoki K
• 通讯作者: Sonoki K

Adiponectin : Production, Regulation and Roles in Disease. Chapter 4-Adiponectin and macrophage

脂联素：产生、调节和在疾病中的作用。

• 发表时间: 2012
• 作者: Akifusa S;Yamashita Y
• 通讯作者: Yamashita Y

Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species

二酰甘油激酶α调节球状脂联素诱导的活性氧

• DOI: 10.3109/10715762.2010.532495
• 发表时间: 2011
• 期刊: Free Radic Res
• 作者: Kamio N;Akifusa S;Yamashita Y
• 通讯作者: Yamashita Y

Geriatrics

• DOI: 10.1136/bmj.1.5448.1486-a
• 发表时间: 1965-06
• 期刊: British Medical Journal
• 作者: J. N. Agate