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Effect of senescent adipose tissue on periodontal disease states

Effect of senescent adipose tissue on periodontal disease states
衰老脂肪组织对牙周病状态的影响
批准号:
23390482
负责人:
AKIFUSA Sumio
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
we investigated whether newly identified adipokine apelin had an inhibitory effect on inflammatory response in lipopolysaccharide (LPS) -treated macrophage. Pretreatment with apelin significantly reduced the production of proinflammatory cytokines in LPS-treated macrophage-like cell line, J774.1 cell. In addition, apelin pretreatment significantly reduced the LPS-induced phosphorylation of p38 MAPK and JNK, but not ERK. To the best of our knowledge, this is the first report that the apelin peptide family has anti-inflammatory effects against bacterial LPS stimulation in macrophages.
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DOI: 10.1111/j.1447-0594.2012.00855.x
发表时间: 2013-01-01
期刊: GERIATRICS & GERONTOLOGY INTERNATIONAL
影响因子: 3.3
作者: [Kikutani, Takeshi, Yoshida, Mitsuyoshi, Tamura, Fumio]
通讯作者: Tamura, Fumio
Activities of daily living dependency and disease-specific mortality during 12-year follow-up in an 80-year-old population
80 岁人群 12 年随访期间的日常生活依赖活动和疾病特异性死亡率
DOI: 10.1007/s40520-013-0029-6
发表时间: 2013
期刊: Aging Clin Exp Res
影响因子: 4
作者: [Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Akifusa S, Goto K, Yoshida A, Sonoki K]
通讯作者: Sonoki K
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Akifusa S, Yamashita Y]
通讯作者: Yamashita Y
Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species
二酰甘油激酶α调节球状脂联素诱导的活性氧
DOI: 10.3109/10715762.2010.532495
发表时间: 2011
期刊: Free Radic Res
影响因子: --
作者: [Kamio N, Akifusa S, Yamashita Y]
通讯作者: Yamashita Y
21
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