Investigation of effect of soluble factors from adipose tissue on periodontitis, and development of prophylactic approach with these regulation

研究脂肪组织可溶性因子对牙周炎的影响，并开发利用这些调节的预防方法

• 批准号: 20592457
• 负责人: AKIFUSA Sumio
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592457/
• 关键词: メタボリックシンドローム; 歯周疾患; 肥満

We examined the effect of adiponectin, one of adipokine derived from mature adipocyte, on activity of macrophage, and found that administration of adiponectin reduced the lipopolysaccharide-induced inflammatory response. On the other hand, stimulation with adiponectin alone induced cytokine secretion, generation of reactive oxygen species and nitric oxide, followed by apoptotic cell death, in macrophage.

我们检测了脂联素对巨噬细胞活性的影响，脂联素是一种来源于成熟脂肪细胞的脂肪因子，给予脂联素可以减轻内毒素诱导的炎症反应。另一方面，单用脂联素刺激可诱导巨噬细胞分泌细胞因子，产生活性氧和一氧化氮，继而导致细胞死亡。

项目成果

Relationship between obesity and physical fitness and periodontitis.

肥胖与体质与牙周炎的关系。

• 发表时间: 2010
• 期刊: 81(8)
• 作者: Shimazaki Y;Egami Y;Matsubara T;Koike G;Akifusa S;Jingu S;Yamashita Y.
• 通讯作者: Yamashita Y.

Involvement of the JAK-STAT Pathway and SOCS3 in the Regulation of Adiponectin-Generated Reactive Oxygen Species in Murine Macrophage RAW 264 Cells

• DOI: 10.1002/jcb.22745
• 发表时间: 2010-10-15
• 期刊: JOURNAL OF CELLULAR BIOCHEMISTRY
• 影响因子: 4
• 作者: Akifusa, Sumio;Kamio, Noriaki;Yamashita, Yoshihisa
• 通讯作者: Yamashita, Yoshihisa

Relationship between chewing ability and high-level functional capacity in an 80-year-old population in Japan

日本80岁老年人咀嚼能力与高级功能能力的关系

• 发表时间: 2008
• 期刊: Gerodontology 25
• 作者: Takata Y;Ansai T;Soh I;Akifusa S;Sonoki K;Fujisawa K;Yoshida A;Kagiyama S;Hamasaki T;Nakamichi I;Awano S;Torisu T;Takehara T
• 通讯作者: Takehara T

Anti-inflammatory activity of a globular adiponectin function on RAW 264 cells stimulated by lipopolysaccharide from Aggregatibacter actinomycetemcomitans

• DOI: 10.1111/j.1574-695x.2009.00573.x
• 发表时间: 2009-08-01
• 期刊: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
• 作者: Kamio, Noriaki;Akifusa, Sumio;Yamashita, Yoshihisa
• 通讯作者: Yamashita, Yoshihisa

Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species

• DOI: 10.3109/10715760903348328
• 发表时间: 2010-02-01
• 期刊: FREE RADICAL RESEARCH
• 影响因子: 3.3
• 作者: Fujimoto, Akie;Akifusa, Sumio;Yamashita, Yoshihisa
• 通讯作者: Yamashita, Yoshihisa