Analysis of hippocampal newborn neurons related to the left-right asymmetry and memory formation

海马新生神经元左右不对称与记忆形成相关的分析

• 批准号: 23500463
• 负责人: KATAGIRI Hiroyuki
• 金额: $ 3.49万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500463/
• 关键词: ニューロン; シナプス; 神経回路; 新生ニューロン

Spatial memory is one of the laterality of the high-order brain function. In the hippocampal dentate gyrus which plays an important role in spatial memory, newborn granule neurons continue to be generated throughout the life. In order to examine the existence of left-right asymmetry in developing newborn neurons, I focused on the excitatory inputs from contralateral mossy cells to newborn neurons. Moreover, injection of replication-defective retrovirus into the sub-granule zones of juvenile mice allowed us to distinguish newborn neurons from pre-existing neurons. The information obtained from this study may lead to investigation of new aspects of adult neurogenesis and functional laterality to understand mechanisms of memory formation.

空间记忆是高阶脑功能的侧向性之一。在对空间记忆起重要作用的海马齿状回中，新生颗粒神经元在一生中不断生成。为了研究新生神经元发育过程中左右不对称的存在，我着重研究了对侧苔藓细胞对新生神经元的兴奋性输入。此外，将复制缺陷逆转录病毒注射到幼鼠的亚颗粒区，使我们能够区分新生神经元和原有神经元。本研究所得的信息可能会导致对成人神经发生和功能侧性的新方面的研究，以了解记忆形成的机制。