Development of prediction and evaluation model of deformability of erythrocyte

分别对红细胞通过微通道和微管单轴拉伸两个实验进行了数值模拟，结果表明，可以通过考察红细胞的变形行为来评价红细胞变形性的变化，红细胞的变形性受红细胞膜内液粘度和膜杨氏模数的影响。制作了微囊作为体外红细胞模型，进行了微板压缩实验和尖头压痕实验。结果表明，通过对实验和变形模型计算得到的力-位移曲线进行拟合，可以识别微胶囊的力学性能，即变形能力。

Numerical simulations were performed corresponding to the following two experiments: an erythrocyte was passed through a micro-channel, and an erythrocyte was stretched uniaxially using micropipettes.As a result, it was shown that the evaluation of the change in the deformability of an erythrocyte is possible by examining the deformation behavior and that the deformability is influenced by the changes in the inner solution viscosity and the membrane Young's modulus of the erythrocyte. Microcapsule was produced as a model of in-vitro model of erythrocyte, and micro-plate compression experiment and indentation experiment using a sharp indenter were performed. It was shown that the mechanical properties, that is deformability, of a microcapsule are identified by fitting the force-displacement curves between the experiment and the deformation model calculation.