Development of prediction and evaluation model of deformability of erythrocyte

红细胞变形能力预测评价模型的建立

• 批准号: 23500532
• 负责人: BANDO Kiyoshi
• 金额: $ 3.33万
• 依托单位: Kansai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500532/
• 关键词: バイオメカニクス; 医用工学; 赤血球; マイクロカプセル; 変形能; ＡＦＭ; マイクロマニピュレータ; 力学特性評価; AFM; モデリング; 力学特性; 時定数; 数値シミュレーション; immersed boundary法; 人工赤血球; マイクロチャンネル

Numerical simulations were performed corresponding to the following two experiments: an erythrocyte was passed through a micro-channel, and an erythrocyte was stretched uniaxially using micropipettes.As a result, it was shown that the evaluation of the change in the deformability of an erythrocyte is possible by examining the deformation behavior and that the deformability is influenced by the changes in the inner solution viscosity and the membrane Young's modulus of the erythrocyte. Microcapsule was produced as a model of in-vitro model of erythrocyte, and micro-plate compression experiment and indentation experiment using a sharp indenter were performed. It was shown that the mechanical properties, that is deformability, of a microcapsule are identified by fitting the force-displacement curves between the experiment and the deformation model calculation.

对应于以下两个实验进行数值模拟：使红细胞通过微通道，并使用微量移液管将红细胞单轴拉伸。结果，结果表明，红细胞的变形能力的变化的评价是可能的，通过检查变形行为和变形能力的影响，在内部溶液粘度和膜杨氏的变化。红细胞的模量。制备微胶囊作为红细胞体外模型的模型，进行了微板压缩实验和压头压入实验。结果表明，力学性能，即变形能力，微胶囊的识别通过拟合的力-位移曲线之间的实验和变形模型计算。

项目成果

Effects of inner solution viscosity and membrane stiffness on erythrocyte deformability on passing through a microchannel: prediction by two-dimensional simulation

内部溶液粘度和膜刚度对红细胞通过微通道变形能力的影响：二维模拟预测

• 发表时间: 2011
• 期刊: Journal of Biorheology
• 作者: A. Kase;K. Bando;K. Ohba
• 通讯作者: K. Ohba

マイクロカプセルの圧縮変形の解析

微胶囊压缩变形分析

• 发表时间: 2011
• 作者: 板東潔;大場謙吉;大礒勇太;九鬼弘
• 通讯作者: 九鬼弘

赤血球の単軸引張に関する変形解析および実験

红细胞单轴拉伸变形分析与实验

• 发表时间: 2014
• 作者: 永井勇大;加藤陽介;板東潔;加瀬篤志;郡慎平;田地川勉
• 通讯作者: 田地川勉

単軸引張から解放された赤血球の変形挙動に関する3次元数値シミュレーショ

单轴拉伸释放红细胞变形行为的3D数值模拟

• 发表时间: 2013
• 作者: 市川智紀;加瀬篤志;板東潔
• 通讯作者: 板東潔

Numerical simulation of erythrocyte deformation behavior under the uni-axial stretching in static fluid

静态流体中单轴拉伸下红细胞变形行为的数值模拟

• 发表时间: 2013
• 作者: A. Kase;T. Ichikawa;K. Bando
• 通讯作者: K. Bando