Development of prediction and evaluation model of deformability of erythrocyte

对应于以下两个实验进行数值模拟：使红细胞通过微通道，并使用微量移液管将红细胞单轴拉伸。结果，结果表明，红细胞的变形能力的变化的评价是可能的，通过检查变形行为和变形能力的影响，在内部溶液粘度和膜杨氏的变化。红细胞的模量。制备微胶囊作为红细胞体外模型的模型，进行了微板压缩实验和压头压入实验。结果表明，力学性能，即变形能力，微胶囊的识别通过拟合的力-位移曲线之间的实验和变形模型计算。

Numerical simulations were performed corresponding to the following two experiments: an erythrocyte was passed through a micro-channel, and an erythrocyte was stretched uniaxially using micropipettes.As a result, it was shown that the evaluation of the change in the deformability of an erythrocyte is possible by examining the deformation behavior and that the deformability is influenced by the changes in the inner solution viscosity and the membrane Young's modulus of the erythrocyte. Microcapsule was produced as a model of in-vitro model of erythrocyte, and micro-plate compression experiment and indentation experiment using a sharp indenter were performed. It was shown that the mechanical properties, that is deformability, of a microcapsule are identified by fitting the force-displacement curves between the experiment and the deformation model calculation.