The development of anti-atherogenic exercise program by regulating skeletal muscle inflammation

M1巨噬细胞，而不是M0或M2巨噬细胞，它们对oxLDL有特征性反应，与NF-kB信号有关。M1在动脉瘤病变和腹腔巨噬细胞中占优势。在动脉粥样硬化形成的小鼠骨骼肌中检测到炎症细胞。自愿运动和强迫运动通过抑制巨噬细胞积聚和炎症反应来减少动脉粥样硬化的形成。心脏康复改善了肌肉质量、肌肉力量和运动耐受性。运动能力与临床预后相关。这些结果表明，保持身体活动可能通过抗炎作用改善动脉粥样硬化的发生和进展。

M1 macrophages, but not M0 or M2 macrophages, which characteristically respond to oxLDL, were associated with NF-kB signaling. M1 was dominant in aneurysmal lesions and peritoneal macrophages. Inflammatory cells were detected in skeletal muscles in mice with atherosclerotic formation. Voluntary exercise as well as forced exercise reduced atherosclerotic formation via inhibition of macrophage accumulation and inflammatory reaction. Cardiac rehabilitation improved muscle mass, muscle strength, and exercise tolerance. Exercise capacity was associated with clinical prognosis. These results suggested that maintaining physical activity may ameliorate the initiation and progression of atherosclerosis through anti-inflammatory effects.