The development of anti-atherogenic exercise program by regulating skeletal muscle inflammation

通过调节骨骼肌炎症抗动脉粥样硬化运动方案的开发

• 批准号: 23500620
• 负责人: SHIMADA Kazunori
• 金额: $ 3.08万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500620/
• 关键词: 動脈硬化; マクロファージ; 骨格筋

M1 macrophages, but not M0 or M2 macrophages, which characteristically respond to oxLDL, were associated with NF-kB signaling. M1 was dominant in aneurysmal lesions and peritoneal macrophages. Inflammatory cells were detected in skeletal muscles in mice with atherosclerotic formation. Voluntary exercise as well as forced exercise reduced atherosclerotic formation via inhibition of macrophage accumulation and inflammatory reaction. Cardiac rehabilitation improved muscle mass, muscle strength, and exercise tolerance. Exercise capacity was associated with clinical prognosis. These results suggested that maintaining physical activity may ameliorate the initiation and progression of atherosclerosis through anti-inflammatory effects.

M1 巨噬细胞与 NF-kB 信号传导相关，但 M0 或 M2 巨噬细胞则不然，它们对 oxLDL 具有典型反应。 M1在动脉瘤性病变和腹膜巨噬细胞中占主导地位。在形成动脉粥样硬化的小鼠骨骼肌中检测到炎症细胞。自愿运动和强迫运动通过抑制巨噬细胞积聚和炎症反应来减少动脉粥样硬化的形成。心脏康复改善了肌肉质量、肌肉力量和运动耐力。运动能力与临床预后相关。这些结果表明，保持体力活动可以通过抗炎作用改善动脉粥样硬化的发生和进展。

项目成果

Diversity and Plasticity of Monocyte Subsets

单核细胞亚群的多样性和可塑性

• DOI: 10.1253/circj.cj-12-1052
• 发表时间: 2012
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: 香月靜;金子真人;皆藤正子;辻 哲也;Shimada K.
• 通讯作者: Shimada K.

Effects of Voluntary Exercise on the Progression of Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice: Protective Role against Vascular Inflammation

自愿运动对载脂蛋白 E 缺陷小鼠动脉粥样硬化病变进展的影响：对血管炎症的保护作用

• 发表时间: 2012
• 期刊: Inangural International Academy of Sportology Proceeding
• 作者: Fukao K;Shimada K, et al.
• 通讯作者: Shimada K, et al.

Cardiac Rehabilitation in Post CABG Patients with Coronary Risk Factors

具有冠状动脉危险因素的冠状动脉搭桥术后患者的心脏康复

• 发表时间: 2013
• 作者: Shimada K;Yokoyama M;Masaki M;Kume A;Fukao K;Sai E;Yoshihara T;Sato H;Sunayama S;Tsuruta R;Yamamoto T;Amano A;Daida H
• 通讯作者: Daida H

Effects of cardiac rehabilitation on muscle mass, muscle strength and exercise tolerance, in diabetic patients after coronary artery bypass grafting

心脏康复对糖尿病患者冠状动脉搭桥术后肌肉质量、肌力和运动耐量的影响

• 发表时间: 2012
• 作者: Nishitani M;Shimada K;Sunayama S;Masaki Y;Kume A;Fukao F;Sai E;Ohmura H;Sato H;Yamamoto T;Amano A;Daida H
• 通讯作者: Daida H

Th1/Th2バランス.Heart View循環器のバイオマーカー

Th1/Th2 平衡。Heart View 心血管生物标志物

• 发表时间: 2012
• 作者: 島田和典;高橋修平;恩田俊仁
• 通讯作者: 恩田俊仁