Anti-atherogenic effects of water exercise : Analysis of the mechanism using 3D tissue-engineered vessel

急性冠脉综合征（ACS）患者的树突状细胞（DCs）活化标志物CCL19和CCR7的表达明显高于非ACS患者。自愿运动通过抑制免疫细胞（如dc、巨噬细胞、淋巴细胞）的积累，改善动脉粥样硬化的发生和进展。在3D组织工程血管中，壁嵌dc对脂多糖有反应，从而刺激自身CD4 T细胞。有运动习惯（包括水上运动）的受试者CRP和CCL19水平低于没有运动习惯的受试者。因此，经常运动，包括水中运动，可能具有抗炎和免疫调节作用。

Expression of activation markers of dendritic cells (DCs), such as CCL19 and CCR7, were significantly higher in patients with acute coronary syndrome (ACS) than in patients without ACS. Voluntary exercise ameliorated the initiation and progression of atherosclerosis via inhibition of the accumulation of immune cells, such as DCs, macrophages, lymphocytes. In 3D tissue-engineered vessels, wall-embedded DCs responded to lipopolysaccharide, resulting in stimulating autologous CD4 T cells. The levels of CRP and CCL19 were lower in subjects with exercise habits, including water exercise, than those without exercise habits. Therefore, regular exercise, including water exercise, may have anti-inflammatory and immmunomodulating effects.