Anti-atherogenic effects of water exercise : Analysis of the mechanism using 3D tissue-engineered vessel

水中运动的抗动脉粥样硬化作用：利用3D组织工程血管分析其机制

• 批准号: 20500629
• 负责人: SHIMADA Kazunori
• 金额: $ 2.5万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500629/
• 关键词: 生活習慣病; 水中運動; 動脈硬化; 免疫応答

Expression of activation markers of dendritic cells (DCs), such as CCL19 and CCR7, were significantly higher in patients with acute coronary syndrome (ACS) than in patients without ACS. Voluntary exercise ameliorated the initiation and progression of atherosclerosis via inhibition of the accumulation of immune cells, such as DCs, macrophages, lymphocytes. In 3D tissue-engineered vessels, wall-embedded DCs responded to lipopolysaccharide, resulting in stimulating autologous CD4 T cells. The levels of CRP and CCL19 were lower in subjects with exercise habits, including water exercise, than those without exercise habits. Therefore, regular exercise, including water exercise, may have anti-inflammatory and immmunomodulating effects.

急性冠脉综合征（ACS）患者的树突状细胞（DCs）活化标志物CCL19和CCR7的表达明显高于非ACS患者。自愿运动通过抑制免疫细胞（如dc、巨噬细胞、淋巴细胞）的积累，改善动脉粥样硬化的发生和进展。在3D组织工程血管中，壁嵌dc对脂多糖有反应，从而刺激自身CD4 T细胞。有运动习惯（包括水上运动）的受试者CRP和CCL19水平低于没有运动习惯的受试者。因此，经常运动，包括水中运动，可能具有抗炎和免疫调节作用。

项目成果

Voluntary Exercise for the Prevention of Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice.

自愿运动预防载脂蛋白 E 缺陷小鼠动脉粥样硬化病变的发展。

• 发表时间: 2009
• 作者: 室増男;只野千茅;下瀬良太;重田枝里子;與那正栄;田島多恵子;内藤裕子;牛込伸行;内山靖;與那正栄;下瀬良太;内藤祐子;島田和典
• 通讯作者: 島田和典

Different responses to oxidized low-density lipoproteins in human polarized macrophages.

对人两极化巨噬细胞中氧化的低密度脂蛋白的反应不同。

• DOI: 10.1186/1476-511x-10-1
• 发表时间: 2011-01-04
• 期刊: Lipids in health and disease
• 影响因子: 4.5
• 作者: Hirose K;Iwabuchi K;Shimada K;Kiyanagi T;Iwahara C;Nakayama H;Daida H
• 通讯作者: Daida H

冠動脈硬化の一次予防

冠状动脉粥样硬化的一级预防

• 发表时间: 2010
• 作者: 蔡榮龍;島田和典
• 通讯作者: 島田和典

Short-term 20-mg atorvastatin therapy reduces key inflammatory factors including c-Jun N-terminal kinase and dendritic cells and matrix metalloproteinase expression in human abdominal aortic aneurysmal wall

• DOI: 10.1016/j.atherosclerosis.2009.03.028
• 发表时间: 2009-10-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Kajimoto, Kan;Miyauchi, Katsumi;Daida, Hiroyuki
• 通讯作者: Daida, Hiroyuki

心臓リハビリテーション(動脈硬化と心臓リハビリテーション 16)

心脏康复（动脉硬化与心脏康复16）

• 发表时间: 2011
• 作者: 島田和典;ほか
• 通讯作者: ほか