The role of lipoprotein receptor LR11 in diabetic complications

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We sought the association between soluble form of LR11 (sLR11) and development of nephropathy among patients with type 2 diabetes (T2DM). sLR11 was determined in the serum samples of 39 healthy normoglycemic control subjects, 38 T2DM patients, 34 T2DM patients with microalbuminuria, and 53 T2DM patients with macroalbuminuria. Circulating sLR11 was significantly increased in patients with diabetic nephropathy compared with healthy subjects. Multivariate regression analysis showed that circulating sLR11 is independent contributing factor for urinary albumin to creatinine ratio (beta:0.22), as well as duration of diabetes(beta:-0.22), systolic blood pressure (beta:0.17), HbA1c(beta:0.22) and eGFR(beta:-0.24). Logistic regression analysis indicated that sLR11 was independently associated with diabetic nephropathy, as well as HbA1c and Cre. There is a statistical significant association between LR11 and albuminuria and may be a useful biomarker for the development of diabetic nephropathy.