Effects of deviated food habit on autoimmune and allergic diseases, and their association with intestinal microflora

异常饮食习惯对自身免疫性疾病和过敏性疾病的影响及其与肠道菌群的关系

• 批准号: 23500957
• 负责人: ARIMOCHI Hideki
• 金额: $ 3.41万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500957/
• 关键词: 自己免疫疾患; 自己炎症性疾患; 高脂肪高蔗糖食; コラーゲン誘発関節炎; 自然発症型1型糖尿病; 腸内菌叢; 高脂肪食; 炎症性サイトカイン; 高脂肪高糖分食; NODマウス

To determine the correlation between deviated food habit and autoimmune diseases, and whether the wrong effects of food change on the disease were associated with the intestinal microflora, DBA1/J and NOD mice, which are model mice for rheumatism arthritis and type1 diabetes, respectively, were fed with high fat glucose diet (HFGD). Both strains of mice treated with HFGD showed less incidence and degree of illness than the control diet group, suggesting that HFGD does not have the enhancing effect for the diseases in these experiment models. The genetically modified mice, which are deleted a specific gene related to an autoimmune disease, were fed with high fat diet (HFD), and monitored serum levels of inflammatory cytokines. The cytokine levels were higher in the kockout mice than WT mice, however, HFD did not show any effects on the cytokine levels in both group of mice. These results indicated the change of food could not affect the illness in the experimental models used here.

为探讨饮食习惯改变与自身免疫性疾病的相关性，以及饮食改变对疾病的不良影响是否与肠道菌群有关，将风湿性关节炎和1型糖尿病模型小鼠DBA1/J和NOD小鼠分别饲喂高脂葡萄糖饲料(HFGD)。经HFGD处理的两个品系的小鼠的发病率和患病程度均低于对照组，提示HFGD对这些实验模型中的疾病没有促进作用。这些转基因小鼠被删除了一种与自身免疫性疾病相关的特定基因，并被喂以高脂饮食(HFD)，并监测了血清中炎症细胞因子的水平。基因敲除小鼠的细胞因子水平高于WT小鼠，但HFD对两组小鼠的细胞因子水平均无影响。这些结果表明，在本实验模型中，食物的改变不会影响疾病的发生。

项目成果

In Vitro Cytotoxic Effect of Ethanol Extract Prepared From Sporophyll of Undaria pinnatifida on Human Colorectal Cancer Cells

裙带菜孢子叶乙醇提取物对人结直肠癌细胞的体外细胞毒作用

• DOI: 10.1002/ptr.3527
• 发表时间: 2012
• 期刊: Phytotherapy Research
• 影响因子: 7.2
• 作者: Akamatsu;R;外山未來，安部景奈，赤松利恵;Gaojian Lian;Naoyoshi Nishibori
• 通讯作者: Naoyoshi Nishibori

Manipulation of CD98 Resolves Type 1 Diabetes in Nonobese Diabetic Mice

• DOI: 10.4049/jimmunol.1102586
• 发表时间: 2012-03-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Lian, Gaojian;Arimochi, Hideki;Yasutomo, Koji
• 通讯作者: Yasutomo, Koji

CD98はT細胞の増殖応答に必要である

T 细胞增殖反应需要 CD98

• 发表时间: 2011
• 作者: 安部景奈;赤松利恵;栗原健士
• 通讯作者: 栗原健士