Effects of deviated food habit on autoimmune and allergic diseases, and their association with intestinal microflora

为了确定饮食习惯偏差与自身免疫性疾病之间的相关性，以及食物变化对疾病的错误影响是否与肠道微生物菌群有关，DBA 1/J和NOD小鼠分别是风湿性关节炎和1型糖尿病的模型小鼠，用高脂葡萄糖饮食（HFGD）喂养。HFGD治疗的两个品系的小鼠均显示出比对照饮食组更低的发病率和疾病程度，表明HFGD对这些实验模型中的疾病没有增强作用。这些基因修饰的小鼠被删除了与自身免疫性疾病相关的特定基因，用高脂饮食（HFD）喂养，并监测血清中炎性细胞因子的水平。 kockout小鼠中的细胞因子水平高于WT小鼠，然而，HFD对两组小鼠中的细胞因子水平均未显示任何影响。这些结果表明，在本实验模型中，食物的变化对疾病没有影响。

To determine the correlation between deviated food habit and autoimmune diseases, and whether the wrong effects of food change on the disease were associated with the intestinal microflora, DBA1/J and NOD mice, which are model mice for rheumatism arthritis and type1 diabetes, respectively, were fed with high fat glucose diet (HFGD). Both strains of mice treated with HFGD showed less incidence and degree of illness than the control diet group, suggesting that HFGD does not have the enhancing effect for the diseases in these experiment models. The genetically modified mice, which are deleted a specific gene related to an autoimmune disease, were fed with high fat diet (HFD), and monitored serum levels of inflammatory cytokines. The cytokine levels were higher in the kockout mice than WT mice, however, HFD did not show any effects on the cytokine levels in both group of mice. These results indicated the change of food could not affect the illness in the experimental models used here.