Influence of maternal intake of n-3 fatty acid on fatty acid transport of fetal blood brain barrier

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Epidemiological studies suggest that maternal dietary poor intake of n-3 and some fatty acids may trigger certain mental disorders of fetus. However, the molecular basis of their actions is still unknown. Our findings show that fatty acid binding protein 3 (FABP3) controls fatty acid trafficking in mouse placenta and the transport is important for fetal development. FABP3 also regulates cognitive function and anxiety behaviors. In mouse brain, FABP5 and FABP7 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation.