toxicolgical role of Zn2+ in cell death induced by chemical stress

Zn2 在化学应激诱导的细胞死亡中的毒理学作用

• 批准号: 23510078
• 负责人: OYAMA Yasuo
• 金额: $ 1.66万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23510078/
• 关键词: 細胞毒性; 亜鉛イオン; 亜鉛; 国際情報交換; 酸化ストレス

The toxicological role of Zn2+ in cell death induced by chemical compounds was examined in this study. Micromolar concentrations of Zn2+ potentiated the cytotoxicity of hydrogen peroxide while the chelator of intracellular Zn2+ diminished it. This result suggests an involvement of Zn2+ in the cell death induced by hydrogen peroxide. The chemical compounds that induced the increase in intracellular Zn2+ concentration potentiated the cytotoxicity of hydrogen peroxide. However, the increase in intracellular Zn2+ concentration by the chemical compounds elevated the cellular content of nonprotein thiols, cytoprotective substances. It is suggested that Zn2+ exerts reciprocal actions, cytoprotective and cytotoxic, on the cell death under certain conditions.

本研究检查了 Zn2+ 在化合物诱导的细胞死亡中的毒理学作用。微摩尔浓度的 Zn2+ 增强了过氧化氢的细胞毒性，而细胞内 Zn2+ 的螯合剂则减弱了它。该结果表明 Zn2+ 参与过氧化氢诱导的细胞死亡。诱导细胞内 Zn2+ 浓度增加的化合物增强了过氧化氢的细胞毒性。然而，化合物增加细胞内 Zn2+ 浓度，提高了非蛋白质硫醇和细胞保护物质的细胞含量。这表明Zn2+在某些条件下对细胞死亡发挥相互作用，即细胞保护作用和细胞毒性作用。

项目成果

Clioquinol, a lipophilic Zn2+ chelator, augments and attenuates the cytotoxicity of H2O2: A bell-shaped response curve of the effects of the drug,

Clioquinol 是一种亲脂性 Zn2 螯合剂，可增强和减弱 H2O2 的细胞毒性：药物作用的钟形响应曲线，

• DOI: 10.1039/c3tx50097g
• 发表时间: 2014
• 期刊: Toxicology Research
• 影响因子: 2.1
• 作者: Tomohiro Oyama;Keisuke Oyama;Eri Fukunaga;Hitoshi Ishibashi and Yasuo Oyama
• 通讯作者: Hitoshi Ishibashi and Yasuo Oyama

Some characteristics of membrane Cd^<2+> transport in rat thymocytes: An analysis using Fluo-3

大鼠胸腺细胞膜 Cd^2 > 转运的一些特征：使用 Fluo-3 的分析

• DOI: 10.1007/s10534-011-9444-3
• 发表时间: 2011
• 期刊: Biometals
• 影响因子: 3.5
• 作者: Takuya Kawanai;Masahiro Fujinaga;Kazuki Koizumi;Isao Kurotani;Erika Hashimoto;Masaya Satoh;Shoji Imai;Norikazu Miyoshi;Yasuo Oyama
• 通讯作者: Yasuo Oyama

Tetracaine decreases intracellular Zn2+ concentration by inhibiting Zn2+ influx in rat thymocytes

丁卡因通过抑制大鼠胸腺细胞中 Zn2+ 流入来降低细胞内 Zn2+ 浓度

• 发表时间: 2011
• 期刊: Natural Science Research
• 作者: Fuiii;Y. ; Nishimura;E. ; Kato;Y . ; Harada;K. H. ; Koizumi;A. ; Haraguchi;K.;Koibuchi N;Kaori Kimura 他
• 通讯作者: Kaori Kimura 他

Elevation of Intracellular Ca2+ Level by Triclosan in Rat Thymic Lymphocytes: Increase in Membrane Ca2+ Permeability and Induction of Intracellular Ca2+ Release

• DOI: 10.1248/jhs.57.540
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF HEALTH SCIENCE
• 作者: Tamura, Ikumi;Saito, Minoru;Oyama, Yasuo
• 通讯作者: Oyama, Yasuo

Nanomolar concentrations of zinc pyrithione increase cell susceptability to oxidative stress induced by hydrogen peroxide in rat thymocytes

纳摩尔浓度的吡啶硫酮锌增加大鼠胸腺细胞对过氧化氢诱导的氧化应激的敏感性

• DOI: 10.1016/j.chemosphere.2012.01.052
• 发表时间: 2012
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Morikawa M.;Kino K.*;Suzuki M.;Kobayashi T.;Komori R.;Miyazawa H.;Tomohiro Oyama et al.
• 通讯作者: Tomohiro Oyama et al.