The role of testicular mono-ADP-ribosylation in men with idiopathic infertility
The role of testicular mono-ADP-ribosylation in men with idiopathic infertility
批准号:
23510242
负责人:
TAJIMA Atsushi
金额:
$3.49万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
点击翻译按钮获取中文摘要
英文摘要
ART3 (ADP-ribosyltransferase 3) have been identified as a susceptibility gene for non-obstructive azoospermia (NOA) in humans. The objective of this study was to reveal a molecular and genetic basis for further understanding of pathophysiological roles of testicular ART3 involved in male infertility. (1) A proteomic analysis indicated that ART3 directly interacted with various proteins, some of which were expressed in human testes, and involved in spermatogenesis. (2) Case-control genetic association studies in Japanese populations demonstrated three NOA susceptibility loci, one of which contained a family gene of the ART3-interacting proteins. Thought the proteomic and genetic analyses, we identified promising candidate genes which might have roles in ART3-dependent regulation of spermatogenesis in humans.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Plasma homocysteine and schizophrenia: a gender-specific meta-analysis.
血浆同型半胱氨酸和精神分裂症:性别特异性荟萃分析。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Numata S, Kikuchi K, Tajima A, Kinoshita M, Shimodera S, Tomotake M, Imoto I, Ohmori T.]
通讯作者:
Ohmori T.
生殖補助医療技術が出生時のDNAメチル化状態に及ぼす影響の検討
检查辅助生殖技术对出生时 DNA 甲基化状态的影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Murakami, Y. et al., 久須美真紀]
通讯作者:
久須美真紀
マイクロ RNA ネットワークの遺伝的多様性とヒト疾患との関わり
microRNA网络的遗传多样性及其与人类疾病的关系
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[田嶋敦]
通讯作者:
田嶋敦
関節リウマチにおけるシステムズ・ジェネティクス・アプローチ~感受性遺伝子座から生物学的経路の推定
类风湿性关节炎的系统遗传学方法 - 从易感位点推断生物学途径
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tomita Y, Harao M, Senju S, Imai K, Hirata S, Irie A, Inoue M, Hayashida Y, Yoshimoto K, Shiraishi K, Mori T, Nomori H, Kohrogi H, Nishimura Y, 中岡博史]
通讯作者:
中岡博史
愛知がんセンター大規模病院疫学研究システムに基づくHLAクラスIIアレルとピロリ菌感染に関する横断研究
基于爱知县癌症中心大型医院流行病学研究系统的HLA II类等位基因与幽门螺杆菌感染的横断面研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tomita Y, Harao M, Senju S, Imai K, Hirata S, Irie A, Inoue M, Hayashida Y, Yoshimoto K, Shiraishi K, Mori T, Nomori H, Kohrogi H, Nishimura Y, 中岡博史, 小林文明(監訳), 田嶋敦]
通讯作者:
田嶋敦
共 21 条
Study on the germ cell migration and sex differentiation in domestic chicken
-
批准号:17K08039
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2017
-
负责人:TAJIMA Atsushi
-
依托单位:
The effect of school internships on the integration of concepts and practices
-
批准号:23730621
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.5万
-
财政年份:2011
-
负责人:TAJIMA Atsushi
-
依托单位:
Basic study on the production of somatic nuclear transferred chicken.
-
批准号:16380184
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2004
-
负责人:TAJIMA Atsushi
-
依托单位:
STUDY ON THE CONSERVATION OF AVIAN GNETIC RESOURCES USING PRIMORDIAL GERM CELLS (PGC)
-
批准号:09460123
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$7.42万
-
财政年份:1997
-
负责人:TAJIMA Atsushi
-
依托单位:
Study on Preservation and Survival of Cadaveric Renal Graft with Warm Ischemia
-
批准号:06454454
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.9万
-
财政年份:1994
-
负责人:TAJIMA Atsushi
-
依托单位:
Study on optimized immunosuppression during the period of acute tubular necrosis following cadaveric renal transplantation
-
批准号:62480337
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.35万
-
财政年份:1987
-
负责人:TAJIMA Atsushi
-
依托单位:
Developmenth of the ultrasound device for thr preoperative lacalization of parathyroid tumor
-
批准号:60870057
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$3.2万
-
财政年份:1985
-
负责人:TAJIMA Atsushi
-
依托单位:
海外基金