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The role of testicular mono-ADP-ribosylation in men with idiopathic infertility

The role of testicular mono-ADP-ribosylation in men with idiopathic infertility
睾丸单 ADP 核糖基化在男性特发性不育症中的作用
批准号:
23510242
负责人:
TAJIMA Atsushi
金额:
$3.49万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
ART3 (ADP-ribosyltransferase 3) have been identified as a susceptibility gene for non-obstructive azoospermia (NOA) in humans. The objective of this study was to reveal a molecular and genetic basis for further understanding of pathophysiological roles of testicular ART3 involved in male infertility. (1) A proteomic analysis indicated that ART3 directly interacted with various proteins, some of which were expressed in human testes, and involved in spermatogenesis. (2) Case-control genetic association studies in Japanese populations demonstrated three NOA susceptibility loci, one of which contained a family gene of the ART3-interacting proteins. Thought the proteomic and genetic analyses, we identified promising candidate genes which might have roles in ART3-dependent regulation of spermatogenesis in humans.
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发表时间: 2013
期刊:
影响因子: --
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发表时间: 2012
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发表时间: 2011
期刊:
影响因子: --
作者: [田嶋敦]
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发表时间: 2011
期刊:
影响因子: --
作者: [Tomita Y, Harao M, Senju S, Imai K, Hirata S, Irie A, Inoue M, Hayashida Y, Yoshimoto K, Shiraishi K, Mori T, Nomori H, Kohrogi H, Nishimura Y, 中岡博史]
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21
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    • 批准号:
      17K08039
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2017
    • 负责人:
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    • 依托单位:
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2004
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      TAJIMA Atsushi
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    • 项目类别:
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      1997
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